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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EARS2
All Species:
30.61
Human Site:
Y124
Identified Species:
56.11
UniProt:
Q5JPH6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5JPH6
NP_001077083.1
523
58689
Y124
Q
S
Q
R
L
E
L
Y
A
Q
A
T
E
A
L
Chimpanzee
Pan troglodytes
XP_001162700
523
58613
Y124
Q
S
Q
R
L
E
L
Y
A
Q
A
T
E
A
L
Rhesus Macaque
Macaca mulatta
XP_001094523
523
58733
Y124
Q
S
Q
R
L
E
L
Y
A
Q
A
T
E
A
L
Dog
Lupus familis
XP_536934
523
58363
Y124
Q
S
Q
R
L
E
L
Y
A
Q
A
T
K
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXJ1
523
58308
Y124
Q
S
Q
R
L
A
L
Y
A
Q
A
T
E
A
L
Rat
Rattus norvegicus
NP_001152965
523
58243
Y124
Q
S
Q
R
L
A
L
Y
A
Q
A
T
E
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJ66
502
56936
A116
A
L
L
D
R
G
A
A
Y
R
C
F
C
T
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q0P499
503
57005
T115
A
A
S
S
L
L
N
T
G
H
A
Y
Y
C
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648894
511
58491
Y108
Q
S
Q
R
T
E
I
Y
S
K
A
I
E
E
L
Honey Bee
Apis mellifera
XP_395175
370
42856
Y46
G
S
L
R
T
A
L
Y
N
Y
L
F
A
R
A
Nematode Worm
Caenorhab. elegans
NP_499917
481
55781
A111
R
L
I
D
S
G
H
A
Y
R
C
F
C
S
E
Sea Urchin
Strong. purpuratus
XP_788628
270
30715
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P48525
536
61585
Y124
Q
S
E
R
K
L
I
Y
D
K
Y
V
K
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.2
86
N.A.
85
84.8
N.A.
N.A.
65.7
N.A.
57.1
N.A.
47.4
34.7
37.2
28.6
Protein Similarity:
100
99.6
96.9
92.9
N.A.
92.3
92.3
N.A.
N.A.
79.3
N.A.
71.8
N.A.
64.6
50.2
55.2
38
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
0
N.A.
13.3
N.A.
60
26.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
6.6
N.A.
20
N.A.
80
26.6
20
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
35.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
0
24
8
16
47
0
62
0
8
47
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
16
0
16
8
0
% C
% Asp:
0
0
0
16
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
39
0
0
0
0
0
0
47
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
24
0
0
8
% F
% Gly:
8
0
0
0
0
16
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
16
0
0
0
0
8
0
8
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
16
0
0
16
0
0
% K
% Leu:
0
16
16
0
54
16
54
0
0
0
8
0
0
0
62
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
62
0
54
0
0
0
0
0
0
47
0
0
0
0
0
% Q
% Arg:
8
0
0
70
8
0
0
0
0
16
0
0
0
8
0
% R
% Ser:
0
70
8
8
8
0
0
0
8
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
16
0
0
8
0
0
0
47
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
16
8
8
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _