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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EAPP All Species: 29.7
Human Site: S175 Identified Species: 50.26
UniProt: Q56P03 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q56P03 NP_060923.2 285 32734 S175 Q Q Q P V P N S D A V L N C P
Chimpanzee Pan troglodytes XP_509897 285 32735 S175 Q Q Q P V P N S D A V L N C P
Rhesus Macaque Macaca mulatta XP_001104634 296 33316 S186 Q Q Q P V P N S D A V L N C P
Dog Lupus familis XP_850430 286 32978 S176 Q Q Q P V P N S D A V L N C P
Cat Felis silvestris
Mouse Mus musculus Q5BU09 281 32475 V171 P R Q K Q Q P V P N S D A V L
Rat Rattus norvegicus NP_001128459 280 32140 P171 C Q K Q Q P V P N S D A V L N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512221 286 33024 S176 R Q P V V P T S D A V L N C P
Chicken Gallus gallus XP_421235 287 33535 S177 P Q Q T K P S S V P N S D A V
Frog Xenopus laevis NP_001085682 293 33892 S184 K H Q A M P P S D A I L N C P
Zebra Danio Brachydanio rerio NP_956078 307 34683 S183 K S Q A L P S S D A V L N C P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_498165 467 53727 G357 A R G S D A P G S S E A D G V
Sea Urchin Strong. purpuratus XP_001197735 355 39844 T239 C P P S I P K T D A I L N C P
Poplar Tree Populus trichocarpa XP_002307158 149 16865 K40 K D E L W V Q K K R K G S N S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_196449 150 17037 K40 K D E L W M D K K R D G R T S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 88.1 89.5 N.A. 87.3 87.7 N.A. 74.4 68.9 63.4 61.5 N.A. N.A. N.A. 23.9 41.6
Protein Similarity: 100 99.6 89.8 93.3 N.A. 91.2 91.9 N.A. 82.1 82.2 77.4 73.9 N.A. N.A. N.A. 37.2 59.1
P-Site Identity: 100 100 100 100 N.A. 6.6 13.3 N.A. 73.3 26.6 60 66.6 N.A. N.A. N.A. 0 46.6
P-Site Similarity: 100 100 100 100 N.A. 13.3 33.3 N.A. 80 40 80 86.6 N.A. N.A. N.A. 20 66.6
Percent
Protein Identity: 28.4 N.A. N.A. 27.7 N.A. N.A.
Protein Similarity: 40 N.A. N.A. 40.3 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 0 8 0 0 0 58 0 15 8 8 0 % A
% Cys: 15 0 0 0 0 0 0 0 0 0 0 0 0 58 0 % C
% Asp: 0 15 0 0 8 0 8 0 58 0 15 8 15 0 0 % D
% Glu: 0 0 15 0 0 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 8 0 0 0 15 0 8 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 15 0 0 0 0 % I
% Lys: 29 0 8 8 8 0 8 15 15 0 8 0 0 0 0 % K
% Leu: 0 0 0 15 8 0 0 0 0 0 0 58 0 8 8 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 29 0 8 8 8 0 58 8 8 % N
% Pro: 15 8 15 29 0 72 22 8 8 8 0 0 0 0 58 % P
% Gln: 29 50 58 8 15 8 8 0 0 0 0 0 0 0 0 % Q
% Arg: 8 15 0 0 0 0 0 0 0 15 0 0 8 0 0 % R
% Ser: 0 8 0 15 0 0 15 58 8 15 8 8 8 0 15 % S
% Thr: 0 0 0 8 0 0 8 8 0 0 0 0 0 8 0 % T
% Val: 0 0 0 8 36 8 8 8 8 0 43 0 8 8 15 % V
% Trp: 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _