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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B12
All Species:
34.24
Human Site:
Y272
Identified Species:
62.78
UniProt:
Q53GQ0
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53GQ0
NP_057226.1
312
34324
Y272
L
Q
S
R
T
N
G
Y
L
I
H
A
L
M
G
Chimpanzee
Pan troglodytes
XP_001158375
312
34320
Y272
L
Q
S
R
T
N
G
Y
L
I
H
A
L
M
G
Rhesus Macaque
Macaca mulatta
XP_001113903
312
34903
Y272
L
Q
S
R
T
N
G
Y
L
I
H
V
L
M
G
Dog
Lupus familis
XP_848504
312
34370
Y272
L
Q
S
R
T
T
G
Y
L
I
H
S
L
M
D
Cat
Felis silvestris
Mouse
Mus musculus
O70503
312
34723
Y272
L
Q
T
R
T
T
G
Y
V
I
H
S
L
M
G
Rat
Rattus norvegicus
Q6P7R8
312
34822
Y272
L
Q
T
R
T
T
G
Y
V
I
H
A
I
M
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJG8
331
37589
R288
S
T
L
G
L
S
K
R
T
P
G
Y
W
K
H
Frog
Xenopus laevis
Q8AVY8
318
34842
Y277
L
Q
T
Q
T
N
G
Y
L
P
H
A
I
T
G
Zebra Danio
Brachydanio rerio
Q6P3L6
319
35532
Y278
L
Q
D
Q
T
N
G
Y
F
P
H
A
V
M
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572420
321
35098
Y276
I
A
T
Q
T
A
G
Y
L
P
H
A
L
L
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09517
316
34290
Y272
N
T
S
D
T
T
G
Y
I
T
H
Q
L
Q
L
Sea Urchin
Strong. purpuratus
XP_001179990
285
31136
L246
P
F
Y
V
T
T
K
L
S
K
L
R
R
E
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
P279
L
N
S
S
E
P
F
P
N
T
Y
T
P
W
W
Conservation
Percent
Protein Identity:
100
99.6
85.9
85.5
N.A.
81
81.7
N.A.
N.A.
42.9
61.6
59.2
N.A.
44.2
N.A.
38.6
46.7
Protein Similarity:
100
99.6
90
93.9
N.A.
90
90
N.A.
N.A.
60.1
77.3
74.6
N.A.
63.8
N.A.
55.7
65
P-Site Identity:
100
100
93.3
80
N.A.
73.3
73.3
N.A.
N.A.
0
66.6
66.6
N.A.
46.6
N.A.
40
6.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
93.3
93.3
N.A.
N.A.
6.6
86.6
80
N.A.
73.3
N.A.
46.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
56
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
0
0
0
0
47
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
8
0
0
0
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
77
0
0
0
8
0
0
0
54
% G
% His:
0
0
0
0
0
0
0
0
0
0
77
0
0
0
8
% H
% Ile:
8
0
0
0
0
0
0
0
8
47
0
0
16
0
0
% I
% Lys:
0
0
0
0
0
0
16
0
0
8
0
0
0
8
0
% K
% Leu:
70
0
8
0
8
0
0
8
47
0
8
0
54
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% M
% Asn:
8
8
0
0
0
39
0
0
8
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
8
0
8
0
31
0
0
8
0
0
% P
% Gln:
0
62
0
24
0
0
0
0
0
0
0
8
0
8
8
% Q
% Arg:
0
0
0
47
0
0
0
8
0
0
0
8
8
0
0
% R
% Ser:
8
0
47
8
0
8
0
0
8
0
0
16
0
0
0
% S
% Thr:
0
16
31
0
85
39
0
0
8
16
0
8
0
8
8
% T
% Val:
0
0
0
8
0
0
0
0
16
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% W
% Tyr:
0
0
8
0
0
0
0
77
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _