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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPPE1 All Species: 7.27
Human Site: T345 Identified Species: 14.55
UniProt: Q53F39 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q53F39 NP_075563.3 396 45141 T345 S I T P T D Y T L S K C Y L P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001095328 396 45252 A345 S I T P T D Y A L S K C Y L P
Dog Lupus familis XP_547678 391 44656 A340 S M T P T E Y A L A K C Y L P
Cat Felis silvestris
Mouse Mus musculus Q80XL7 396 45994 A345 S L T S R D Y A L S K C Y L P
Rat Rattus norvegicus B1WC86 394 45635 A343 S L T S R D Y A L S K C Y L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZK82 398 45772 S347 S I T P T D F S L H K C F L P
Frog Xenopus laevis Q0IHA5 405 46737 T352 S F I M G S I T A T K Y S L A
Zebra Danio Brachydanio rerio Q566Y9 381 44050 Q330 T F S Q S E F Q L S K C F L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLR9 370 43301 V317 T I T P D D Y V V S K C K M L
Honey Bee Apis mellifera XP_625094 383 44994 G331 D N P S L L L G V F T P N N Y
Nematode Worm Caenorhab. elegans Q95X35 473 54796 I359 N I A V C T A I I L V M I I N
Sea Urchin Strong. purpuratus XP_780915 393 44826 S342 S L I L A S I S P T S I A I N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 94.6 78.5 N.A. 73.4 72.9 N.A. N.A. 65 56.7 53.5 N.A. 39.9 42.4 25.3 44.7
Protein Similarity: 100 N.A. 96.7 85.6 N.A. 83 81 N.A. N.A. 75.8 70.3 71.4 N.A. 56.5 62.1 43.1 59.8
P-Site Identity: 100 N.A. 93.3 73.3 N.A. 73.3 73.3 N.A. N.A. 73.3 26.6 40 N.A. 53.3 0 6.6 6.6
P-Site Similarity: 100 N.A. 93.3 93.3 N.A. 80 80 N.A. N.A. 93.3 33.3 80 N.A. 73.3 6.6 26.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 9 0 9 34 9 9 0 0 9 0 9 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 67 0 0 0 % C
% Asp: 9 0 0 0 9 50 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 17 0 0 0 0 17 0 0 9 0 0 17 0 0 % F
% Gly: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 0 42 17 0 0 0 17 9 9 0 0 9 9 17 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 75 0 9 0 0 % K
% Leu: 0 25 0 9 9 9 9 0 59 9 0 0 0 67 9 % L
% Met: 0 9 0 9 0 0 0 0 0 0 0 9 0 9 0 % M
% Asn: 9 9 0 0 0 0 0 0 0 0 0 0 9 9 17 % N
% Pro: 0 0 9 42 0 0 0 0 9 0 0 9 0 0 59 % P
% Gln: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 67 0 9 25 9 17 0 17 0 50 9 0 9 0 0 % S
% Thr: 17 0 59 0 34 9 0 17 0 17 9 0 0 0 0 % T
% Val: 0 0 0 9 0 0 0 9 17 0 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 50 0 0 0 0 9 42 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _