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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GEN1 All Species: 14.55
Human Site: S717 Identified Species: 26.67
UniProt: Q17RS7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q17RS7 NP_001123481.1 908 102884 S717 N S G S D C T S H L S K D L P
Chimpanzee Pan troglodytes XP_001136471 908 102886 S717 N S G S D C T S H L S K D L P
Rhesus Macaque Macaca mulatta XP_001092312 907 102641 S716 N S G S D C T S H L S K D L P
Dog Lupus familis XP_540093 908 102344 H717 S D S D C P S H L A K N L L G
Cat Felis silvestris
Mouse Mus musculus Q8BMI4 908 101761 S710 Y S S S D G S S N F S K D L T
Rat Rattus norvegicus NP_001100187 908 102307 T717 S H F S K D L T G V Y L Q K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518788 839 92658 D622 D D R G Q A N D H L R I S S Q
Chicken Gallus gallus XP_419963 941 105105 E742 Q E G D T L H E M I Q K D H N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRJ0 726 82516 A536 K E G T P V K A P A P Q R Q Q
Honey Bee Apis mellifera XP_001120033 614 70598 G424 E Y M A L N N G S D E I N E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793916 1102 120745 T886 A I L A N S A T G A H T V S P
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001169528 638 71262 I448 D S I E R T K I R H G H P Y Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LPD2 599 67201 E409 L S T I Y L R E K A R N N T G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 94.8 79.1 N.A. 70 70 N.A. 35.9 44.4 N.A. N.A. N.A. 28.2 27.4 N.A. 25.8
Protein Similarity: 100 99.6 96.9 87.5 N.A. 80.7 80.9 N.A. 50.4 60 N.A. N.A. N.A. 44.4 42.6 N.A. 41.7
P-Site Identity: 100 100 100 6.6 N.A. 53.3 6.6 N.A. 13.3 20 N.A. N.A. N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 100 100 20 N.A. 66.6 26.6 N.A. 20 26.6 N.A. N.A. N.A. 26.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. 25 N.A. 25.1 N.A. N.A.
Protein Similarity: N.A. 40.9 N.A. 38.1 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 16 0 8 8 8 0 31 0 0 0 0 0 % A
% Cys: 0 0 0 0 8 24 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 16 0 16 31 8 0 8 0 8 0 0 39 0 8 % D
% Glu: 8 16 0 8 0 0 0 16 0 0 8 0 0 8 8 % E
% Phe: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 39 8 0 8 0 8 16 0 8 0 0 0 16 % G
% His: 0 8 0 0 0 0 8 8 31 8 8 8 0 8 0 % H
% Ile: 0 8 8 8 0 0 0 8 0 8 0 16 0 0 0 % I
% Lys: 8 0 0 0 8 0 16 0 8 0 8 39 0 8 0 % K
% Leu: 8 0 8 0 8 16 8 0 8 31 0 8 8 39 0 % L
% Met: 0 0 8 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 24 0 0 0 8 8 16 0 8 0 0 16 16 0 8 % N
% Pro: 0 0 0 0 8 8 0 0 8 0 8 0 8 0 31 % P
% Gln: 8 0 0 0 8 0 0 0 0 0 8 8 8 8 16 % Q
% Arg: 0 0 8 0 8 0 8 0 8 0 16 0 8 0 0 % R
% Ser: 16 47 16 39 0 8 16 31 8 0 31 0 8 16 0 % S
% Thr: 0 0 8 8 8 8 24 16 0 0 0 8 0 8 8 % T
% Val: 0 0 0 0 0 8 0 0 0 8 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 0 8 0 0 0 0 0 8 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _