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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
28.34
Human Site:
Y498
Identified Species:
47.97
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
Y498
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Chimpanzee
Pan troglodytes
XP_519193
509
57278
Y504
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
Y498
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
Y498
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Rat
Rattus norvegicus
Q64654
503
56688
Y498
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
A544
P
A
G
P
R
N
P
A
R
P
L
G
G
G
A
Chicken
Gallus gallus
Q9PUB4
492
55246
I486
D
N
L
P
A
K
F
I
G
F
S
G
Q
I
_
Frog
Xenopus laevis
NP_001091285
501
56963
Y496
P
N
N
P
V
I
R
Y
K
R
R
K
I
_
_
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
Y490
P
H
N
P
I
I
R
Y
T
R
R
N
T
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
F505
R
T
K
E
P
L
M
F
K
V
R
E
R
V
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
Y489
P
L
N
P
I
I
R
Y
K
R
R
T
E
S
L
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
P493
L
T
V
V
K
K
V
P
L
K
L
V
P
V
R
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
I519
L
P
T
G
P
A
K
I
I
W
E
K
R
N
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
7.1
76.9
53.3
N.A.
13.3
N.A.
N.A.
60
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
26.6
21.4
76.9
66.6
N.A.
40
N.A.
N.A.
80
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
0
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
0
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
8
0
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
36
0
8
0
0
0
0
0
0
8
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
8
8
0
8
0
0
0
0
0
% F
% Gly:
0
0
8
8
0
0
0
0
8
0
0
15
8
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
15
58
0
15
8
0
0
0
8
8
0
% I
% Lys:
0
0
8
0
8
15
8
0
58
8
0
15
36
0
0
% K
% Leu:
15
8
8
0
0
8
0
0
8
0
15
0
0
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
58
0
0
8
0
0
0
0
0
8
0
8
0
% N
% Pro:
65
8
0
72
15
0
8
8
0
8
0
0
8
0
15
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% Q
% Arg:
8
0
0
0
8
0
58
0
8
58
65
0
15
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
8
36
0
8
0
% S
% Thr:
0
15
8
0
0
0
0
0
8
0
0
8
8
0
0
% T
% Val:
0
0
8
8
43
0
8
0
0
8
0
8
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
58
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
43
50
% _