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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
23.03
Human Site:
Y338
Identified Species:
38.97
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
Y338
K
T
L
Q
K
K
C
Y
L
E
Q
K
T
V
C
Chimpanzee
Pan troglodytes
XP_519193
509
57278
Y344
K
T
L
Q
E
K
C
Y
L
E
Q
K
T
V
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
Y338
K
T
L
Q
D
K
C
Y
L
E
Q
K
T
V
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
Y338
K
P
L
Q
E
K
C
Y
L
E
Q
K
A
V
C
Rat
Rattus norvegicus
Q64654
503
56688
Y338
K
P
L
Q
D
K
C
Y
L
E
Q
K
T
V
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
F374
Y
A
D
L
D
G
G
F
S
H
A
A
W
L
L
Chicken
Gallus gallus
Q9PUB4
492
55246
Q326
Q
K
V
R
K
E
L
Q
L
K
G
L
L
S
G
Frog
Xenopus laevis
NP_001091285
501
56963
F336
K
S
L
Q
N
Q
C
F
A
E
Q
K
A
V
C
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
Y330
R
A
L
Q
E
R
C
Y
S
E
Q
K
S
V
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
F343
P
E
A
Q
K
K
C
F
E
E
I
R
S
V
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
N328
K
E
V
Q
D
R
C
N
A
E
Q
I
K
V
C
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
D328
K
K
H
G
N
K
V
D
H
D
I
L
S
E
M
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
Q331
P
E
L
M
K
N
V
Q
G
E
I
R
D
S
F
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
Y341
P
D
V
Q
Q
E
L
Y
E
E
Q
M
R
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
93.3
N.A.
93.3
N.A.
80
86.6
N.A.
0
13.3
60
60
N.A.
40
N.A.
N.A.
46.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
13.3
46.6
80
86.6
N.A.
60
N.A.
N.A.
60
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
33.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
0
0
0
0
0
15
0
8
8
15
0
0
% A
% Cys:
0
0
0
0
0
0
65
0
0
0
0
0
0
0
58
% C
% Asp:
0
8
8
0
29
0
0
8
0
8
0
0
8
0
0
% D
% Glu:
0
22
0
0
22
15
0
0
15
79
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
22
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
0
8
8
0
8
0
8
0
0
0
8
% G
% His:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
22
8
0
0
0
% I
% Lys:
58
15
0
0
29
50
0
0
0
8
0
50
8
0
0
% K
% Leu:
0
0
58
8
0
0
15
0
43
0
0
15
8
8
15
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
0
0
15
8
0
8
0
0
0
0
0
0
0
% N
% Pro:
22
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
72
8
8
0
15
0
0
65
0
0
0
0
% Q
% Arg:
8
0
0
8
0
15
0
0
0
0
0
15
8
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
15
0
0
0
22
15
0
% S
% Thr:
0
22
0
0
0
0
0
0
0
0
0
0
29
0
0
% T
% Val:
0
0
22
0
0
0
15
0
0
0
0
0
0
72
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
8
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _