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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
34.85
Human Site:
Y227
Identified Species:
58.97
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
Y227
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Chimpanzee
Pan troglodytes
XP_519193
509
57278
Y233
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
Y227
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
Y227
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Rat
Rattus norvegicus
Q64654
503
56688
Y227
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
F258
S
D
A
A
A
L
L
F
N
S
K
N
E
D
L
Chicken
Gallus gallus
Q9PUB4
492
55246
L219
F
E
E
M
I
R
N
L
F
S
L
P
I
D
V
Frog
Xenopus laevis
NP_001091285
501
56963
Y225
N
E
R
V
A
Q
L
Y
A
D
L
D
G
G
F
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
Y219
D
E
R
V
A
Q
L
Y
A
D
L
D
G
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
L234
R
F
D
L
T
Y
M
L
T
P
L
A
R
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
Y218
D
E
E
V
A
Q
L
Y
A
D
L
D
G
G
F
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
P221
S
V
L
F
P
Y
L
P
I
P
A
H
R
R
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
F221
S
F
T
C
S
D
F
F
P
I
A
G
L
G
W
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
Y229
D
T
D
F
A
Y
L
Y
S
D
L
D
K
G
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
13.3
93.3
86.6
N.A.
6.6
N.A.
N.A.
86.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
40
33.3
100
100
N.A.
20
N.A.
N.A.
100
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
53.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
33.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
72
0
0
0
58
0
15
8
0
8
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
8
15
0
0
8
0
0
0
65
0
65
0
15
0
% D
% Glu:
0
65
15
0
0
0
0
0
0
0
0
0
8
0
8
% E
% Phe:
8
15
0
15
0
0
8
15
8
0
0
0
0
0
65
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
58
72
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
8
0
0
8
0
0
% I
% Lys:
0
0
36
0
0
0
0
0
0
0
8
0
8
0
0
% K
% Leu:
0
0
8
8
0
8
79
15
0
0
79
0
8
0
8
% L
% Met:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
43
0
0
0
0
0
8
0
8
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
8
8
15
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
58
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
15
0
0
8
0
0
0
0
0
0
15
8
8
% R
% Ser:
22
0
0
0
8
0
0
0
8
15
0
0
0
0
0
% S
% Thr:
0
8
8
0
8
0
0
0
8
0
0
0
0
0
0
% T
% Val:
0
8
0
58
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
22
0
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _