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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUK1
All Species:
44.85
Human Site:
Y53
Identified Species:
82.22
UniProt:
Q16774
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16774
NP_000849.1
197
21726
Y53
G
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
Chimpanzee
Pan troglodytes
XP_001142469
475
50955
Y119
G
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
Rhesus Macaque
Macaca mulatta
XP_001084363
197
21679
Y53
G
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
Dog
Lupus familis
XP_532411
198
21967
Y53
G
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
Cat
Felis silvestris
Mouse
Mus musculus
Q64520
198
21899
Y53
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
Rat
Rattus norvegicus
NP_001013133
219
24034
Y74
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232001
198
22316
Y53
G
E
V
N
G
K
D
Y
H
F
V
T
R
E
E
Frog
Xenopus laevis
NP_001087146
198
21955
Y53
G
E
V
D
G
K
D
Y
H
F
V
T
L
E
D
Zebra Danio
Brachydanio rerio
NP_001002126
199
21965
Y53
G
E
E
N
G
K
D
Y
H
F
V
S
R
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648408
233
25880
Y84
G
E
E
H
G
V
H
Y
Y
F
V
E
R
P
E
Honey Bee
Apis mellifera
XP_624407
194
22137
Y55
G
E
E
D
G
K
H
Y
H
F
T
T
K
E
K
Nematode Worm
Caenorhab. elegans
NP_491243
216
24871
Y73
G
E
E
H
G
K
H
Y
Y
F
T
E
K
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P15454
187
20619
V54
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.1
98.4
88.8
N.A.
87.8
78
N.A.
N.A.
73.2
68.1
71.8
N.A.
47.6
54.3
50
N.A.
Protein Similarity:
100
40.4
98.9
92.9
N.A.
92.9
84.4
N.A.
N.A.
87.3
82.3
84.9
N.A.
60.5
73
63.4
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
80
66.6
86.6
N.A.
60
60
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
86.6
80
100
N.A.
66.6
80
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
68.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
39
0
0
70
0
0
0
8
0
0
0
8
% D
% Glu:
0
93
77
0
0
0
0
0
0
0
0
24
0
85
16
% E
% Phe:
0
0
0
0
0
0
8
0
0
93
0
0
8
0
0
% F
% Gly:
93
8
0
0
93
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
16
0
0
24
0
31
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
85
0
0
0
0
0
0
16
8
16
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% M
% Asn:
8
0
0
47
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
70
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
16
70
0
0
0
% T
% Val:
0
0
16
0
0
8
0
8
0
8
77
0
0
0
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
93
62
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _