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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLPP All Species: 17.88
Human Site: T37 Identified Species: 30.26
UniProt: Q16740 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16740 NP_006003.1 277 30180 T37 A Q R P P Q R T L Q N G L A L
Chimpanzee Pan troglodytes XP_512312 277 30084 T37 A P R P P Q R T P Q N G L A L
Rhesus Macaque Macaca mulatta XP_001087805 270 28896 T37 A Q R P P Q R T P Q N G L A L
Dog Lupus familis XP_854538 273 29694 T33 A R F P P R R T P R T G L A L
Cat Felis silvestris
Mouse Mus musculus O88696 272 29782 T33 V H F S P P W T A V S C S P L
Rat Rattus norvegicus XP_001055676 333 36190 S94 V R F S P P W S T G S D S P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001088816 247 27316 C26 T Q L R N V H C S P P I L S P
Zebra Danio Brachydanio rerio NP_001018520 266 28920 S27 H Q S S P W S S P L I P I V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609388 253 27555 I27 R A N S V R N I N L I P M V V
Honey Bee Apis mellifera XP_392540 237 26294 K17 Q I F V P G Q K V S K R Y L N
Nematode Worm Caenorhab. elegans Q27539 221 24247
Sea Urchin Strong. purpuratus XP_786892 239 26099 C19 S S K L G G L C H R S L H N G
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147355 260 28004 Y35 G Y I P R R E Y G L V P M V I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FN42 241 26265 T21 S T P S S M A T S I A T G R R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 71.4 90.2 N.A. 85.9 70.2 N.A. N.A. N.A. 72.1 71.4 N.A. 56.6 59.2 49 62.4
Protein Similarity: 100 98.9 76.1 91.6 N.A. 88 72.9 N.A. N.A. N.A. 79 79.7 N.A. 68.2 69.3 61.7 73.2
P-Site Identity: 100 86.6 93.3 60 N.A. 20 13.3 N.A. N.A. N.A. 13.3 13.3 N.A. 0 6.6 0 0
P-Site Similarity: 100 86.6 93.3 80 N.A. 26.6 33.3 N.A. N.A. N.A. 20 33.3 N.A. 20 20 0 26.6
Percent
Protein Identity: N.A. 52.7 N.A. 48.3 N.A. N.A.
Protein Similarity: N.A. 66.4 N.A. 64.9 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 26.6 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 29 8 0 0 0 0 8 0 8 0 8 0 0 29 0 % A
% Cys: 0 0 0 0 0 0 0 15 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 8 15 0 0 8 8 0 29 8 0 8 % G
% His: 8 8 0 0 0 0 8 0 8 0 0 0 8 0 0 % H
% Ile: 0 8 8 0 0 0 0 8 0 8 15 8 8 0 8 % I
% Lys: 0 0 8 0 0 0 0 8 0 0 8 0 0 0 0 % K
% Leu: 0 0 8 8 0 0 8 0 8 22 0 8 36 8 43 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 15 0 0 % M
% Asn: 0 0 8 0 8 0 8 0 8 0 22 0 0 8 8 % N
% Pro: 0 8 8 36 58 15 0 0 29 8 8 22 0 15 8 % P
% Gln: 8 29 0 0 0 22 8 0 0 22 0 0 0 0 0 % Q
% Arg: 8 15 22 8 8 22 29 0 0 15 0 8 0 8 8 % R
% Ser: 15 8 8 36 8 0 8 15 15 8 22 0 15 8 0 % S
% Thr: 8 8 0 0 0 0 0 43 8 0 8 8 0 0 0 % T
% Val: 15 0 0 8 8 8 0 0 8 8 8 0 0 22 15 % V
% Trp: 0 0 0 0 0 8 15 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 8 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _