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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STXBP2 All Species: 12.42
Human Site: S454 Identified Species: 19.52
UniProt: Q15833 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.57
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15833 NP_008880 593 66439 S454 T V T N P G G S G T S S R L E
Chimpanzee Pan troglodytes XP_001153467 595 66736 S456 T V T N P G G S G T S S R L E
Rhesus Macaque Macaca mulatta XP_001097163 644 70907 N483 R L T T D K A N I K D L S Q I
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q64324 593 66339 S454 T V T N S A G S G T S S R L E
Rat Rattus norvegicus Q62753 594 66677 S454 T V T N S A G S G T S S R L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508183 589 67400 R443 I I T D S T L R R R S K P E R
Chicken Gallus gallus Q6R748 594 67454 R457 I I T D S T L R R R S K P E R
Frog Xenopus laevis NP_001093335 595 67691 R458 I I T D S S L R R R S K P D R
Zebra Danio Brachydanio rerio NP_998454 595 67030 N456 P I I T G G A N S G K S L P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07327 597 67832 K465 N V I A D S R K K Q Y S V P R
Honey Bee Apis mellifera XP_396375 585 66573 K455 V V D G G N R K K L Y T V Q R
Nematode Worm Caenorhab. elegans P34815 673 76715 K538 I V T D T G R K K T W T P T K
Sea Urchin Strong. purpuratus NP_999834 593 68046 R458 I I H N Q R S R K T K P T P R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SZ77 662 75299 K498 P L K F D V L K T K R A A R R
Baker's Yeast Sacchar. cerevisiae P30619 724 83462 F492 D K P K D K P F Q K E W F H D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 72.5 N.A. N.A. 94.9 94.4 N.A. 61.3 63.6 62.3 68 N.A. 56.1 56.3 47.8 52.6
Protein Similarity: 100 99.1 72.9 N.A. N.A. 97.1 97.1 N.A. 78.2 80.3 80 82.1 N.A. 72.6 74.5 64 72.3
P-Site Identity: 100 100 6.6 N.A. N.A. 86.6 86.6 N.A. 13.3 13.3 13.3 13.3 N.A. 13.3 6.6 26.6 13.3
P-Site Similarity: 100 100 20 N.A. N.A. 86.6 86.6 N.A. 26.6 26.6 26.6 33.3 N.A. 13.3 13.3 46.6 20
Percent
Protein Identity: N.A. N.A. N.A. 28.8 25.4 N.A.
Protein Similarity: N.A. N.A. N.A. 49.7 42.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 14 14 0 0 0 0 7 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 27 27 0 0 0 0 0 7 0 0 7 14 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 7 0 0 14 27 % E
% Phe: 0 0 0 7 0 0 0 7 0 0 0 0 7 0 0 % F
% Gly: 0 0 0 7 14 27 27 0 27 7 0 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 34 34 14 0 0 0 0 0 7 0 0 0 0 0 7 % I
% Lys: 0 7 7 7 0 14 0 27 27 20 14 20 0 0 7 % K
% Leu: 0 14 0 0 0 0 27 0 0 7 0 7 7 27 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 34 0 7 0 14 0 0 0 0 0 0 0 % N
% Pro: 14 0 7 0 14 0 7 0 0 0 0 7 27 20 0 % P
% Gln: 0 0 0 0 7 0 0 0 7 7 0 0 0 14 0 % Q
% Arg: 7 0 0 0 0 7 20 27 20 20 7 0 27 7 47 % R
% Ser: 0 0 0 0 34 14 7 27 7 0 47 40 7 0 0 % S
% Thr: 27 0 60 14 7 14 0 0 7 40 0 14 7 7 0 % T
% Val: 7 47 0 0 0 7 0 0 0 0 0 0 14 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _