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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3C All Species: 23.64
Human Site: S486 Identified Species: 37.14
UniProt: Q15386 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15386 NP_055486.2 1083 123923 S486 L Q V I S R G S P M S F E D S
Chimpanzee Pan troglodytes XP_528010 1089 124652 S492 L Q V I S R G S P M S F E D S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539937 1088 124202 S491 L Q V I S R G S P M S L E D S
Cat Felis silvestris
Mouse Mus musculus Q80U95 1083 123957 S486 L Q L I S R G S P M S F E D S
Rat Rattus norvegicus Q62940 887 102376 L359 A E E L D T R L T M Y G N P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510756 1084 124281 S487 L Q V I S R G S P M S L E D S
Chicken Gallus gallus NP_001026138 1084 124128 S487 L Q V I S R G S P M S L D E S
Frog Xenopus laevis Q6DCL5 944 106566 D416 E L T K N K R D S S N I A C I
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 R237 E R R V R S Q R H R N Y M S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611896 1122 128925 K532 I S K G V V P K H Q G V D R T
Honey Bee Apis mellifera XP_396547 1033 119022 I480 L H D T E F F I Q D Q S L D I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797123 1037 118587 F483 M S L H D S E F Y G D D A D S
Poplar Tree Populus trichocarpa XP_002314972 1027 117409 C474 L W N F M K Q C H E N K K W P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWB8 1029 117643 Y473 L V A V L W N Y M K R C H E N
Baker's Yeast Sacchar. cerevisiae P53119 910 105547 T382 E L K K F T S T L K D F T F R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 N.A. 95.4 N.A. 93.3 22.1 N.A. 91.4 90.6 22.8 22.5 N.A. 39.7 43 N.A. 44.2
Protein Similarity: 100 98.1 N.A. 97.4 N.A. 97.2 38.4 N.A. 95.6 94.8 39 38.3 N.A. 61 62.7 N.A. 61.6
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 6.6 N.A. 93.3 80 0 0 N.A. 0 13.3 N.A. 13.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 26.6 N.A. 93.3 93.3 20 26.6 N.A. 20 13.3 N.A. 26.6
Percent
Protein Identity: 28.3 N.A. N.A. 28.7 26.7 N.A.
Protein Similarity: 47 N.A. N.A. 49 44.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 0 0 0 0 0 0 0 0 0 14 0 7 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 7 0 7 0 % C
% Asp: 0 0 7 0 14 0 0 7 0 7 14 7 14 47 0 % D
% Glu: 20 7 7 0 7 0 7 0 0 7 0 0 34 14 0 % E
% Phe: 0 0 0 7 7 7 7 7 0 0 0 27 0 7 0 % F
% Gly: 0 0 0 7 0 0 40 0 0 7 7 7 0 0 0 % G
% His: 0 7 0 7 0 0 0 0 20 0 0 0 7 0 0 % H
% Ile: 7 0 0 40 0 0 0 7 0 0 0 7 0 0 14 % I
% Lys: 0 0 14 14 0 14 0 7 0 14 0 7 7 0 0 % K
% Leu: 60 14 14 7 7 0 0 7 7 0 0 20 7 0 0 % L
% Met: 7 0 0 0 7 0 0 0 7 47 0 0 7 0 0 % M
% Asn: 0 0 7 0 7 0 7 0 0 0 20 0 7 0 7 % N
% Pro: 0 0 0 0 0 0 7 0 40 0 0 0 0 7 7 % P
% Gln: 0 40 0 0 0 0 14 0 7 7 7 0 0 0 0 % Q
% Arg: 0 7 7 0 7 40 14 7 0 7 7 0 0 7 14 % R
% Ser: 0 14 0 0 40 14 7 40 7 7 40 7 0 7 47 % S
% Thr: 0 0 7 7 0 14 0 7 7 0 0 0 7 0 7 % T
% Val: 0 7 34 14 7 7 0 0 0 0 0 7 0 0 0 % V
% Trp: 0 7 0 0 0 7 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 0 0 0 0 7 7 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _