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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP2R5A All Species: 31.52
Human Site: S178 Identified Species: 53.33
UniProt: Q15172 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15172 NP_006234.1 486 56194 S178 E S P D F Q P S I A K R Y I D
Chimpanzee Pan troglodytes XP_001151388 673 75031 S404 E S P D F Q P S I A K R Y I D
Rhesus Macaque Macaca mulatta XP_001106979 628 70785 S338 E S P D F Q P S I A K R Y I D
Dog Lupus familis XP_547400 566 64736 S258 E S P D F Q P S I A K R Y I D
Cat Felis silvestris
Mouse Mus musculus Q6PD03 486 56328 S178 E S P D F Q P S I A K R Y I D
Rat Rattus norvegicus NP_001101361 486 56318 S178 E S P D F Q P S I A K R Y I D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509703 483 55774 S174 E S P D F Q P S I A K R F I D
Chicken Gallus gallus XP_419432 476 55266 K171 D F Q P S I A K R F I D Q K F
Frog Xenopus laevis NP_001086500 476 55192 Q175 I A K R F V D Q K F V Q Q L L
Zebra Danio Brachydanio rerio XP_690932 478 56125 S170 E N P D F Q P S T A K R Y I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651569 524 59708 V170 Q A T I G K R V I D Q K F V L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780697 432 50137 K170 E F Q P S I A K K Y I D Q K F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LU89 510 58740 K221 A S P E T D T K L A K R Y I D
Baker's Yeast Sacchar. cerevisiae P38903 757 85316 Q402 E S P D F N H Q I A K Q Y I D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 65.6 74.3 85.1 N.A. 97.7 97.9 N.A. 95 93.2 88 80 N.A. 66.7 N.A. N.A. 68.3
Protein Similarity: 100 66.1 74.5 85.1 N.A. 98.7 98.7 N.A. 97.5 95.8 94 88.8 N.A. 78 N.A. N.A. 78.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 0 6.6 86.6 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 6.6 26.6 93.3 N.A. 53.3 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 48.2 37.5 N.A.
Protein Similarity: N.A. N.A. N.A. 65.2 49.5 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 73.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 0 0 0 0 15 0 0 72 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 65 0 8 8 0 0 8 0 15 0 0 72 % D
% Glu: 72 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 15 0 0 72 0 0 0 0 15 0 0 15 0 15 % F
% Gly: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 8 0 15 0 0 65 0 15 0 0 72 0 % I
% Lys: 0 0 8 0 0 8 0 22 15 0 72 8 0 15 0 % K
% Leu: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 15 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 72 15 0 0 58 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 15 0 0 58 0 15 0 0 8 15 22 0 0 % Q
% Arg: 0 0 0 8 0 0 8 0 8 0 0 65 0 0 0 % R
% Ser: 0 65 0 0 15 0 0 58 0 0 0 0 0 0 0 % S
% Thr: 0 0 8 0 8 0 8 0 8 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 8 0 8 0 0 8 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 65 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _