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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
12.42
Human Site:
S247
Identified Species:
22.78
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
S247
C
D
L
Y
Y
I
N
S
P
E
L
E
L
E
E
Chimpanzee
Pan troglodytes
XP_515910
436
49246
S247
C
D
L
Y
Y
I
N
S
P
E
L
E
L
E
E
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
S232
C
D
L
Y
Y
I
N
S
P
E
L
E
L
G
E
Dog
Lupus familis
XP_548195
458
51349
D271
K
Y
Y
M
A
S
P
D
L
E
I
Q
E
I
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
E247
L
Y
Y
V
N
S
P
E
L
E
L
E
E
L
N
Rat
Rattus norvegicus
Q63065
434
49063
E247
L
Y
Y
V
N
S
P
E
L
E
L
E
E
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
L208
Y
Y
I
N
S
P
E
L
K
L
V
E
L
N
A
Chicken
Gallus gallus
NP_001026523
408
46413
L222
Y
Y
M
S
S
P
E
L
V
L
E
E
L
N
I
Frog
Xenopus laevis
NP_001085016
412
46992
P224
D
L
Y
Y
M
S
S
P
E
L
E
L
T
E
F
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
L219
Y
Y
M
N
S
P
E
L
V
L
E
E
F
N
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
E224
Y
L
T
S
P
A
L
E
I
Q
Q
H
S
S
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
S215
C
D
R
Y
Y
L
T
S
P
S
M
K
L
E
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
Y268
Q
K
F
I
Q
D
M
Y
F
K
D
I
P
M
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
93.3
6.6
N.A.
20
20
N.A.
13.3
13.3
13.3
6.6
N.A.
6.6
N.A.
53.3
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
20
20
N.A.
26.6
20
20
13.3
N.A.
13.3
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
8
% A
% Cys:
31
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
31
0
0
0
8
0
8
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
24
24
8
47
24
62
24
31
31
% E
% Phe:
0
0
8
0
0
0
0
0
8
0
0
0
8
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
8
8
0
24
0
0
8
0
8
8
0
8
8
% I
% Lys:
8
8
0
0
0
0
0
0
8
8
0
8
0
0
0
% K
% Leu:
16
16
24
0
0
8
8
24
24
31
39
8
47
16
0
% L
% Met:
0
0
16
8
8
0
8
0
0
0
8
0
0
8
8
% M
% Asn:
0
0
0
16
16
0
24
0
0
0
0
0
0
24
24
% N
% Pro:
0
0
0
0
8
24
24
8
31
0
0
0
8
0
8
% P
% Gln:
8
0
0
0
8
0
0
0
0
8
8
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
16
24
31
8
31
0
8
0
0
8
8
0
% S
% Thr:
0
0
8
0
0
0
8
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
16
0
0
0
0
16
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
31
47
31
39
31
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _