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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHPRH All Species: 27.27
Human Site: Y781 Identified Species: 60
UniProt: Q149N8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q149N8 NP_001036148.1 1683 193079 Y781 V L R S E L N Y V D I P H S N
Chimpanzee Pan troglodytes XP_001172976 1683 193077 Y781 V L R S E L N Y V D I P H S N
Rhesus Macaque Macaca mulatta XP_001086512 1683 193033 Y781 V L R S E L N Y V D I P H S N
Dog Lupus familis XP_533438 1685 193077 Y783 V L R S E L N Y V D I P H S N
Cat Felis silvestris
Mouse Mus musculus Q7TPQ3 1674 191472 Y772 V L R S E L N Y V N I P H S N
Rat Rattus norvegicus NP_001100940 1701 194686 Y779 V L R S E L N Y V D I P H S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506895 1042 119725 I255 P Q P L Y S L I A K I M W R S
Chicken Gallus gallus XP_419651 1681 192161 Y780 V L R T E L N Y V D I P H S N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648034 1270 148040 P483 R P E V C R P P D A W Q T V D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002329202 1320 149464 E534 S L K T Y V Y E G V R D T S L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_181609 1664 188054 N769 A E A A K L L N S L L K L R Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 98 92.5 N.A. 86 84.6 N.A. 52.7 72 N.A. N.A. N.A. 25.6 N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.9 95.7 N.A. 91.8 90.7 N.A. 56.9 82.2 N.A. N.A. N.A. 42.3 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 100 N.A. 6.6 93.3 N.A. N.A. N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 100 N.A. N.A. N.A. 6.6 N.A. N.A. N.A.
Percent
Protein Identity: 20.9 N.A. N.A. 20.8 N.A. N.A.
Protein Similarity: 37.7 N.A. N.A. 38.6 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 0 0 0 0 10 10 0 0 0 0 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 10 55 0 10 0 0 10 % D
% Glu: 0 10 10 0 64 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 64 0 0 % H
% Ile: 0 0 0 0 0 0 0 10 0 0 73 0 0 0 0 % I
% Lys: 0 0 10 0 10 0 0 0 0 10 0 10 0 0 0 % K
% Leu: 0 73 0 10 0 73 19 0 0 10 10 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 64 10 0 10 0 0 0 0 64 % N
% Pro: 10 10 10 0 0 0 10 10 0 0 0 64 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 10 % Q
% Arg: 10 0 64 0 0 10 0 0 0 0 10 0 0 19 0 % R
% Ser: 10 0 0 55 0 10 0 0 10 0 0 0 0 73 10 % S
% Thr: 0 0 0 19 0 0 0 0 0 0 0 0 19 0 0 % T
% Val: 64 0 0 10 0 10 0 0 64 10 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % W
% Tyr: 0 0 0 0 19 0 10 64 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _