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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
32.12
Human Site:
Y226
Identified Species:
50.48
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
Y226
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
Y226
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
Y226
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
Dog
Lupus familis
XP_538730
651
74149
Y226
K
K
I
M
R
G
K
Y
E
V
P
K
W
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
R223
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
Rat
Rattus norvegicus
P54645
559
63955
N155
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
Y228
K
K
I
T
K
G
K
Y
M
V
P
K
W
L
S
Chicken
Gallus gallus
NP_001026680
657
74208
Y228
R
R
I
T
R
G
K
Y
A
V
P
K
W
L
S
Frog
Xenopus laevis
NP_001081569
651
74289
Y228
K
K
I
M
R
G
K
Y
E
I
P
K
W
L
S
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
F273
A
R
V
L
S
G
K
F
R
I
P
F
F
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
L202
M
G
V
L
L
Y
A
L
L
C
G
F
L
P
F
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
F228
K
K
I
Q
S
G
C
F
Y
E
P
E
F
L
S
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
Y502
R
K
I
L
S
G
V
Y
E
E
P
P
W
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
T36
K
F
A
R
N
S
E
T
G
E
P
V
A
L
K
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Y217
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
93.3
N.A.
0
0
N.A.
80
73.3
86.6
26.6
N.A.
N.A.
0
46.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
13.3
33.3
N.A.
86.6
86.6
100
73.3
N.A.
N.A.
13.3
66.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
7
0
0
0
7
0
14
7
0
0
14
0
0
% A
% Cys:
0
0
7
0
0
0
7
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
20
0
0
7
0
0
0
% D
% Glu:
0
0
0
0
0
0
14
0
20
20
0
20
0
0
0
% E
% Phe:
0
7
0
0
0
0
0
14
0
0
0
14
14
0
7
% F
% Gly:
0
7
0
7
0
67
0
0
14
0
7
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
60
0
0
7
0
0
0
14
0
0
0
7
0
% I
% Lys:
54
54
0
7
20
0
54
0
0
7
0
47
0
0
14
% K
% Leu:
0
7
0
27
7
0
0
7
7
7
7
0
7
67
0
% L
% Met:
7
0
0
34
0
0
7
0
7
0
0
0
0
7
7
% M
% Asn:
0
0
0
0
7
0
7
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
14
0
0
0
0
80
7
0
14
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
14
20
0
7
40
0
0
7
7
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
27
7
0
0
0
0
0
0
0
0
74
% S
% Thr:
7
0
0
14
0
0
0
7
0
0
0
0
0
0
0
% T
% Val:
0
0
14
0
0
0
7
0
7
40
0
7
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
54
0
0
% W
% Tyr:
0
0
7
0
0
7
0
60
7
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _