Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 21.82
Human Site: T300 Identified Species: 34.29
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 T300 H H R N N R Q T M E D L I S L
Chimpanzee Pan troglodytes XP_001168921 651 74605 T300 H H R N N R Q T M E D L I S L
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 T300 H H R N N R Q T M E D L I S L
Dog Lupus familis XP_538730 651 74149 T300 H H R N N R Q T M E D L I S L
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 R295 T E L S V H H R S S R Q T M E
Rat Rattus norvegicus P54645 559 63955 D227 C G T L P F D D D H V P T L F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 T302 Y F K R N K Q T M E K L I S M
Chicken Gallus gallus NP_001026680 657 74208 N302 F H N K S R E N I S A L I S K
Frog Xenopus laevis NP_001081569 651 74289 S302 F Y K Y S R T S T T R L I S E
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 T356 M G F D R E R T L Q S L H A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 V274 F L N P V S F V H K T N F Q K
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 D302 Y Y G F E S T D K M I E K I K
Sea Urchin Strong. purpuratus XP_781767 971 109658 D576 H Y G K S K K D I T S T L K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 R108 D K I V N D G R M K E D E A R
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 N290 I K R M L I V N P L N R I S I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 100 100 N.A. 0 0 N.A. 53.3 33.3 26.6 13.3 N.A. N.A. 0 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 6.6 0 N.A. 80 53.3 53.3 46.6 N.A. N.A. 6.6 13.3 46.6
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 7 0 0 14 0 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 7 0 7 7 20 7 0 27 7 0 0 7 % D
% Glu: 0 7 0 0 7 7 7 0 0 34 7 7 7 0 14 % E
% Phe: 20 7 7 7 0 7 7 0 0 0 0 0 7 0 7 % F
% Gly: 0 14 14 0 0 0 7 0 0 0 0 0 0 0 0 % G
% His: 34 34 0 0 0 7 7 0 7 7 0 0 7 0 0 % H
% Ile: 7 0 7 0 0 7 0 0 14 0 7 0 54 7 7 % I
% Lys: 0 14 14 14 0 14 7 0 7 14 7 0 7 7 20 % K
% Leu: 0 7 7 7 7 0 0 0 7 7 0 54 7 7 27 % L
% Met: 7 0 0 7 0 0 0 0 40 7 0 0 0 7 7 % M
% Asn: 0 0 14 27 40 0 0 14 0 0 7 7 0 0 0 % N
% Pro: 0 0 0 7 7 0 0 0 7 0 0 7 0 0 0 % P
% Gln: 0 0 0 0 0 0 34 0 0 7 0 7 0 7 7 % Q
% Arg: 0 0 34 7 7 40 7 14 0 0 14 7 0 0 7 % R
% Ser: 0 0 0 7 20 14 0 7 7 14 14 0 0 54 0 % S
% Thr: 7 0 7 0 0 0 14 40 7 14 7 7 14 0 0 % T
% Val: 0 0 0 7 14 0 7 7 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 14 20 0 7 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _