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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM6
All Species:
46.36
Human Site:
S746
Identified Species:
63.75
UniProt:
Q14566
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14566
NP_005906.2
821
92889
S746
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Chimpanzee
Pan troglodytes
XP_001154613
821
92903
S746
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Rhesus Macaque
Macaca mulatta
XP_001096068
821
92830
S746
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Dog
Lupus familis
XP_533338
955
107181
S880
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Cat
Felis silvestris
Mouse
Mus musculus
P97311
821
92849
S746
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Rat
Rattus norvegicus
Q62724
507
57351
W437
K
R
S
E
L
V
N
W
Y
L
K
E
I
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510510
779
87819
S703
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Chicken
Gallus gallus
NP_001006527
916
103481
S751
D
D
S
S
L
K
K
S
E
L
I
N
W
Y
L
Frog
Xenopus laevis
Q7ZY18
825
93359
S750
N
E
T
S
Q
R
K
S
E
L
I
N
W
Y
L
Zebra Danio
Brachydanio rerio
XP_002662351
830
93777
S753
D
E
A
A
L
K
K
S
E
V
V
N
W
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V461
817
92334
S741
N
D
T
G
I
K
R
S
N
V
V
T
W
Y
L
Honey Bee
Apis mellifera
XP_396515
813
91942
S741
A
K
G
G
L
K
K
S
E
L
V
A
W
Y
L
Nematode Worm
Caenorhab. elegans
P34647
810
91112
E740
E
D
N
Q
G
E
D
E
Y
D
G
V
K
Q
S
Sea Urchin
Strong. purpuratus
XP_783166
823
93674
S741
G
F
E
G
V
R
K
S
D
V
V
N
W
Y
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
V690
S
G
N
D
P
M
D
V
D
V
G
S
N
D
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
Q646
S
L
Y
A
D
D
R
Q
K
A
G
L
D
A
I
Baker's Yeast
Sacchar. cerevisiae
P53091
1017
112934
V934
G
A
E
E
L
T
A
V
D
I
V
D
W
Y
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.7
83.8
N.A.
95.8
58.9
N.A.
84.7
78.5
82.6
80.9
N.A.
63.5
59.8
54.8
71.5
Protein Similarity:
100
100
100
84.7
N.A.
97.6
60.5
N.A.
89.7
84.8
91.1
89.2
N.A.
79
76.3
71.7
84.2
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
100
73.3
53.3
80
N.A.
46.6
60
0
40
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
93.3
100
N.A.
80
73.3
26.6
73.3
Percent
Protein Identity:
N.A.
26.4
N.A.
25.8
38.5
N.A.
Protein Similarity:
N.A.
45.6
N.A.
44.7
56.5
N.A.
P-Site Identity:
N.A.
0
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
6
48
0
0
6
0
0
6
0
6
0
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
48
18
0
6
6
6
12
0
18
6
0
6
6
6
0
% D
% Glu:
6
48
12
12
0
6
0
6
59
0
0
6
0
6
0
% E
% Phe:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
6
6
18
6
0
0
0
0
0
18
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
6
0
0
0
0
6
12
0
6
0
6
% I
% Lys:
6
6
0
0
0
59
30
0
6
0
6
0
6
0
0
% K
% Leu:
0
6
0
0
65
0
0
0
0
59
0
6
0
0
77
% L
% Met:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
12
0
0
0
6
0
6
0
0
59
6
0
0
% N
% Pro:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
6
6
0
0
6
0
0
0
0
0
6
6
% Q
% Arg:
0
6
0
0
0
12
48
0
0
0
0
0
0
0
0
% R
% Ser:
12
0
48
12
0
0
0
71
0
0
0
6
0
0
12
% S
% Thr:
0
0
12
0
0
6
0
0
0
0
0
6
0
0
0
% T
% Val:
0
0
0
0
6
6
0
12
0
24
65
6
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
6
0
0
0
0
77
0
0
% W
% Tyr:
0
0
6
0
0
0
0
0
12
0
0
0
0
77
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _