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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCN5A All Species: 27.27
Human Site: Y774 Identified Species: 66.67
UniProt: Q14524 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14524 NP_000326.2 2016 226940 Y774 K I I A L D P Y Y Y F Q Q G W
Chimpanzee Pan troglodytes XP_001171891 2016 226990 Y774 K I I A L D P Y Y Y F Q Q G W
Rhesus Macaque Macaca mulatta XP_001099916 2017 229324 Y828 K I I A M D P Y Y Y F Q E G W
Dog Lupus familis XP_849362 2012 228642 Y823 K I I A M D P Y Y Y F Q E G W
Cat Felis silvestris
Mouse Mus musculus Q9JJV9 2019 227604 Y774 K I I A L D P Y Y Y F Q Q G W
Rat Rattus norvegicus P15389 2019 227349 Y775 K I I A L D P Y Y Y F Q Q G W
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232818 2040 231951 Y783 K V I A L D P Y Y Y F Q Q G W
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q20JQ7 1784 201644 L655 M L A D V E G L S V L R S F R
Tiger Blowfish Takifugu rubipres Q2XVR7 1892 213080 M753 F I F A V V G M Q L F G K S Y
Fruit Fly Dros. melanogaster P35500 2131 239344 K875 K L M A M S P K Y Y F Q E G W
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 64.5 64.6 N.A. 94.4 94 N.A. N.A. 76.4 N.A. 57.5 58.1 44 N.A. N.A. N.A.
Protein Similarity: 100 99.5 77 77.1 N.A. 96.5 96.2 N.A. N.A. 85.1 N.A. 69.8 70.7 60.3 N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 86.6 N.A. 100 100 N.A. N.A. 93.3 N.A. 0 20 60 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 N.A. 26.6 40 86.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 90 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 70 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 10 0 0 0 0 0 0 30 0 0 % E
% Phe: 10 0 10 0 0 0 0 0 0 0 90 0 0 10 0 % F
% Gly: 0 0 0 0 0 0 20 0 0 0 0 10 0 80 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 70 70 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 80 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % K
% Leu: 0 20 0 0 50 0 0 10 0 10 10 0 0 0 0 % L
% Met: 10 0 10 0 30 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 80 50 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % R
% Ser: 0 0 0 0 0 10 0 0 10 0 0 0 10 10 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 10 0 0 20 10 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 80 % W
% Tyr: 0 0 0 0 0 0 0 70 80 80 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _