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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
30.91
Human Site:
Y859
Identified Species:
56.67
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Dog
Lupus familis
XP_854529
779
87136
K559
A
I
L
A
T
D
L
K
K
H
F
D
F
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Rat
Rattus norvegicus
Q62865
1141
124282
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
A120
M
A
L
Y
V
A
A
A
M
H
D
Y
D
H
P
Chicken
Gallus gallus
XP_416416
825
91797
V605
L
K
K
H
F
D
F
V
A
K
F
N
A
K
V
Frog
Xenopus laevis
NP_001088828
985
108702
K765
A
I
L
A
T
D
L
K
K
H
F
D
F
L
A
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
Y785
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
Y934
S
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
S405
E
N
H
H
A
A
E
S
W
K
L
L
N
K
P
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
Y1207
S
A
S
Q
A
I
L
Y
N
D
R
S
V
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
13.3
N.A.
100
100
N.A.
6.6
0
13.3
100
N.A.
60
N.A.
6.6
86.6
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
6.6
6.6
20
100
N.A.
80
N.A.
6.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
62
0
16
70
16
8
8
8
0
0
0
8
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
24
0
0
0
62
8
16
8
0
0
% D
% Glu:
8
0
8
0
0
0
8
0
0
0
8
0
0
0
62
% E
% Phe:
0
0
0
0
8
0
8
0
0
0
24
0
16
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
16
0
0
0
0
0
24
0
0
0
8
0
% H
% Ile:
0
16
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
8
0
0
0
0
16
16
16
0
0
0
16
0
% K
% Leu:
8
0
24
8
0
8
70
0
0
0
8
8
0
77
0
% L
% Met:
8
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
62
0
0
8
8
0
0
% N
% Pro:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
16
% P
% Gln:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
54
0
0
0
0
% R
% Ser:
62
8
8
0
0
0
0
8
0
0
0
62
0
0
0
% S
% Thr:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
47
0
8
0
0
0
0
62
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
62
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _