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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
9.7
Human Site:
Y497
Identified Species:
17.78
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
Y497
S
R
S
F
T
S
S
Y
A
I
S
A
A
N
H
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
Y497
S
R
S
F
T
S
S
Y
A
I
S
A
A
N
H
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
Y497
X
X
X
X
X
X
S
Y
A
I
S
A
A
N
H
Dog
Lupus familis
XP_854529
779
87136
L216
G
V
I
L
H
R
S
L
G
S
A
P
N
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
T494
L
T
K
S
R
S
F
T
S
S
Y
A
V
S
A
Rat
Rattus norvegicus
Q62865
1141
124282
T494
L
T
K
S
R
S
F
T
S
S
Y
A
V
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
I262
P
S
L
S
E
P
N
I
S
P
S
V
I
C
S
Frog
Xenopus laevis
NP_001088828
985
108702
P422
S
R
A
P
V
E
F
P
D
T
A
D
F
L
T
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
R431
M
L
S
I
S
K
S
R
S
M
S
A
S
Y
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
A432
S
A
G
G
S
S
S
A
T
T
V
I
G
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
R62
R
T
F
H
E
A
M
R
Q
R
R
T
S
L
P
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
D837
L
S
R
Q
G
G
G
D
G
S
L
K
S
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
60
6.6
N.A.
13.3
13.3
N.A.
0
6.6
13.3
26.6
N.A.
20
N.A.
0
0
P-Site Similarity:
100
100
60
20
N.A.
26.6
26.6
N.A.
0
20
26.6
53.3
N.A.
40
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
0
8
24
0
16
47
24
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
8
8
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
16
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
16
0
0
24
0
0
0
0
0
8
0
0
% F
% Gly:
8
0
8
8
8
8
8
0
16
0
0
0
8
0
0
% G
% His:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
24
% H
% Ile:
0
0
8
8
0
0
0
8
0
24
0
8
8
0
0
% I
% Lys:
0
0
16
0
0
8
0
0
0
0
0
8
0
0
0
% K
% Leu:
24
8
8
8
0
0
0
8
0
0
8
0
0
16
0
% L
% Met:
8
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
8
24
8
% N
% Pro:
8
0
0
8
0
8
0
8
0
8
0
8
0
0
16
% P
% Gln:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
24
8
0
16
8
0
16
0
8
8
0
0
8
0
% R
% Ser:
31
16
24
24
16
39
47
0
31
31
39
0
24
31
16
% S
% Thr:
0
24
0
0
16
0
0
16
8
16
0
8
0
0
8
% T
% Val:
0
8
0
0
8
0
0
0
0
0
8
8
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
24
0
0
16
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _