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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
22.12
Human Site:
S818
Identified Species:
40.56
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Dog
Lupus familis
XP_854529
779
87136
A518
S
V
L
E
N
H
H
A
A
S
A
W
N
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Rat
Rattus norvegicus
Q62865
1141
124282
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
G79
S
D
T
D
S
D
S
G
I
T
P
G
R
V
A
Chicken
Gallus gallus
XP_416416
825
91797
L564
H
A
A
A
A
W
N
L
F
M
S
R
P
E
Y
Frog
Xenopus laevis
NP_001088828
985
108702
A724
S
V
L
E
N
H
H
A
A
S
A
W
N
L
F
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
S744
E
E
G
Y
G
C
L
S
G
L
I
P
A
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
E893
L
L
N
T
P
A
L
E
G
V
F
T
P
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
A364
E
L
M
A
L
F
T
A
A
A
M
H
D
Y
D
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
A1166
D
S
S
Y
G
I
L
A
G
N
L
P
A
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
6.6
0
6.6
73.3
N.A.
26.6
N.A.
0
66.6
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
13.3
0
20
86.6
N.A.
26.6
N.A.
26.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
16
8
8
0
31
24
8
16
0
54
0
8
% A
% Cys:
0
0
0
0
0
47
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
47
0
8
0
8
0
0
0
0
0
0
8
0
8
% D
% Glu:
16
8
0
16
0
0
0
8
0
0
0
0
0
8
62
% E
% Phe:
0
0
0
0
0
8
0
0
8
0
8
0
0
0
8
% F
% Gly:
0
0
8
0
54
0
0
8
62
0
0
8
0
0
0
% G
% His:
8
0
0
0
0
16
16
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
8
0
47
0
0
0
0
% I
% Lys:
0
0
39
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
16
16
0
8
0
62
8
0
8
8
0
0
77
0
% L
% Met:
0
0
8
0
0
0
0
0
0
8
8
0
0
0
0
% M
% Asn:
0
0
8
0
16
0
8
0
0
47
0
0
16
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
8
54
16
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% R
% Ser:
24
8
8
0
8
0
8
47
0
16
8
0
0
0
0
% S
% Thr:
0
0
8
8
0
0
8
0
0
8
0
8
0
0
0
% T
% Val:
0
16
0
0
0
0
0
0
0
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
16
0
0
0
% W
% Tyr:
0
0
0
54
0
0
0
0
0
0
0
0
0
8
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _