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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
11.82
Human Site:
S575
Identified Species:
21.67
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
S575
T
Q
S
A
P
D
L
S
P
Q
I
L
T
P
P
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
S575
T
Q
S
A
P
D
L
S
P
Q
I
L
T
P
P
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
S575
T
Q
S
A
P
D
L
S
P
Q
I
L
T
P
P
Dog
Lupus familis
XP_854529
779
87136
R294
E
T
E
N
G
D
Y
R
K
L
F
L
E
G
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
P572
L
T
Y
T
Q
S
A
P
D
L
S
P
Q
I
P
Rat
Rattus norvegicus
Q62865
1141
124282
P572
L
T
Y
T
Q
S
A
P
D
L
S
P
Q
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
T340
R
K
G
S
V
C
R
T
Y
A
P
E
T
I
I
Frog
Xenopus laevis
NP_001088828
985
108702
K500
A
E
S
G
T
G
Q
K
E
A
G
H
L
K
E
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
S509
K
A
L
T
H
S
Q
S
A
P
S
S
S
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
S510
G
D
L
Q
K
Y
H
S
R
Y
L
K
N
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
Y140
P
S
V
V
E
N
P
Y
G
G
E
S
M
V
V
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
E915
D
D
D
T
S
R
L
E
E
L
S
N
Q
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
13.3
N.A.
6.6
6.6
N.A.
0
6.6
6.6
6.6
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
100
100
13.3
N.A.
6.6
6.6
N.A.
0
26.6
13.3
13.3
N.A.
13.3
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
24
0
0
16
0
8
16
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
8
0
0
31
0
0
16
0
0
0
0
0
8
% D
% Glu:
8
8
8
0
8
0
0
8
16
0
8
8
8
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
8
0
8
8
8
8
0
0
8
8
8
0
0
8
0
% G
% His:
0
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
24
0
0
24
16
% I
% Lys:
8
8
0
0
8
0
0
8
8
0
0
8
0
8
0
% K
% Leu:
16
0
16
0
0
0
31
0
0
31
8
31
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
8
8
0
0
% N
% Pro:
8
0
0
0
24
0
8
16
24
8
8
16
0
31
39
% P
% Gln:
0
24
0
8
16
0
16
0
0
24
0
0
24
0
0
% Q
% Arg:
8
0
0
0
0
8
8
8
8
0
0
0
0
8
8
% R
% Ser:
0
8
31
8
8
24
0
39
0
0
31
16
8
0
0
% S
% Thr:
24
24
0
31
8
0
0
8
0
0
0
0
31
0
0
% T
% Val:
0
0
8
8
8
0
0
0
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
0
0
8
8
8
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _