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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE3A All Species: 20.61
Human Site: S1030 Identified Species: 37.78
UniProt: Q14432 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14432 NP_000912.3 1141 124979 S1030 P G K W V E D S D E S G D T D
Chimpanzee Pan troglodytes XP_520783 1141 125048 S1030 P G K W V E D S D E S G D T D
Rhesus Macaque Macaca mulatta XP_001096963 1141 124707 S1030 P G K W V E D S D E S G D T D
Dog Lupus familis XP_854529 779 87136 D692 T E S C Y D E D G E E L D S D
Cat Felis silvestris
Mouse Mus musculus Q9Z0X4 1141 124494 S1030 P G K W V D D S D D S G D T D
Rat Rattus norvegicus Q62865 1141 124282 S1030 P G K W V D D S D D S G D T D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518516 340 38206 D253 Y N F L S N L D H V E F K R F
Chicken Gallus gallus XP_416416 825 91797 C738 E T A E M E T C E N A E S R K
Frog Xenopus laevis NP_001088828 985 108702 L898 E S D D N D D L D S E E E E M
Zebra Danio Brachydanio rerio XP_695432 1117 123518 L958 P G R W V H P L P K D G D E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W4T4 1209 129395 T1109 D A Q D I L D T L E E N R D Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q8I0P7 625 69850 S538 S F I A H V V S P L A T A M N
Sea Urchin Strong. purpuratus XP_793920 1558 171759 E1380 P G R W L D E E D D D R K S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.5 38.2 N.A. 84 84.6 N.A. 20.9 59.6 43.9 57.8 N.A. 20.8 N.A. 26.7 29.9
Protein Similarity: 100 99.7 98.4 49.6 N.A. 89.3 90 N.A. 25.1 63.9 58.3 71.2 N.A. 36.3 N.A. 37.9 43.2
P-Site Identity: 100 100 100 20 N.A. 86.6 86.6 N.A. 0 6.6 13.3 40 N.A. 13.3 N.A. 6.6 26.6
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. 0 26.6 26.6 53.3 N.A. 33.3 N.A. 20 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 0 0 0 0 16 0 8 0 0 % A
% Cys: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 16 0 39 54 16 54 24 16 0 54 8 47 % D
% Glu: 16 8 0 8 0 31 16 8 8 39 31 16 8 16 0 % E
% Phe: 0 8 8 0 0 0 0 0 0 0 0 8 0 0 8 % F
% Gly: 0 54 0 0 0 0 0 0 8 0 0 47 0 0 0 % G
% His: 0 0 0 0 8 8 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 39 0 0 0 0 0 0 8 0 0 16 0 8 % K
% Leu: 0 0 0 8 8 8 8 16 8 8 0 8 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 8 % M
% Asn: 0 8 0 0 8 8 0 0 0 8 0 8 0 0 8 % N
% Pro: 54 0 0 0 0 0 8 0 16 0 0 0 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 16 0 0 0 0 0 0 0 0 8 8 16 8 % R
% Ser: 8 8 8 0 8 0 0 47 0 8 39 0 8 16 0 % S
% Thr: 8 8 0 0 0 0 8 8 0 0 0 8 0 39 0 % T
% Val: 0 0 0 0 47 8 8 0 0 8 0 0 0 0 8 % V
% Trp: 0 0 0 54 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _