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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F2
All Species:
7.27
Human Site:
T220
Identified Species:
14.55
UniProt:
Q14209
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14209
NP_004082.1
437
47506
T220
E
L
K
E
L
M
N
T
E
Q
A
L
D
Q
L
Chimpanzee
Pan troglodytes
XP_524538
437
47536
M220
E
L
K
E
L
M
N
M
E
Q
A
L
D
Q
L
Rhesus Macaque
Macaca mulatta
XP_001102839
437
47573
I220
E
L
K
E
L
M
N
I
E
E
A
L
D
Q
L
Dog
Lupus familis
XP_545361
509
56204
S289
N
V
Q
W
M
G
C
S
L
S
E
D
G
G
M
Cat
Felis silvestris
Mouse
Mus musculus
P56931
443
48481
A222
E
L
K
E
L
M
N
A
E
Q
T
L
D
Q
L
Rat
Rattus norvegicus
Q62814
300
33206
R84
N
T
K
E
V
I
D
R
L
R
C
L
K
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
S251
G
T
G
L
F
G
D
S
T
A
V
R
Q
Q
Q
Chicken
Gallus gallus
Q90977
403
43534
K185
S
R
Q
R
L
L
E
K
E
L
R
D
L
Q
A
Frog
Xenopus laevis
NP_001081986
429
46399
S209
N
I
Q
W
M
G
C
S
L
P
D
D
G
G
N
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
P207
S
D
G
G
L
P
S
P
A
M
Q
S
H
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
T480
N
N
I
D
A
M
S
T
K
G
L
F
Q
T
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
T185
L
E
G
I
K
L
I
T
K
K
S
K
N
N
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.1
43
N.A.
83
20.5
N.A.
52.7
40.9
43.9
40
N.A.
20.6
N.A.
N.A.
42.7
Protein Similarity:
100
99.7
98.6
55
N.A.
87.5
34.7
N.A.
62.3
54.9
55.1
55.3
N.A.
31.7
N.A.
N.A.
55.3
P-Site Identity:
100
93.3
86.6
0
N.A.
86.6
20
N.A.
6.6
20
0
13.3
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
93.3
33.3
N.A.
86.6
46.6
N.A.
20
33.3
26.6
20
N.A.
33.3
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
9
9
9
25
0
0
9
9
% A
% Cys:
0
0
0
0
0
0
17
0
0
0
9
0
0
0
0
% C
% Asp:
0
9
0
9
0
0
17
0
0
0
9
25
34
0
0
% D
% Glu:
34
9
0
42
0
0
9
0
42
9
9
0
0
0
9
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
9
0
25
9
0
25
0
0
0
9
0
0
17
17
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
9
9
9
0
9
9
9
0
0
0
0
0
0
9
% I
% Lys:
0
0
42
0
9
0
0
9
17
9
0
9
9
0
0
% K
% Leu:
9
34
0
9
50
17
0
0
25
9
9
42
9
0
42
% L
% Met:
0
0
0
0
17
42
0
9
0
9
0
0
0
0
9
% M
% Asn:
34
9
0
0
0
0
34
0
0
0
0
0
9
9
9
% N
% Pro:
0
0
0
0
0
9
0
9
0
9
0
0
0
0
9
% P
% Gln:
0
0
25
0
0
0
0
0
0
25
9
0
17
50
9
% Q
% Arg:
0
9
0
9
0
0
0
9
0
9
9
9
0
0
0
% R
% Ser:
17
0
0
0
0
0
17
25
0
9
9
9
0
9
0
% S
% Thr:
0
17
0
0
0
0
0
25
9
0
9
0
0
9
0
% T
% Val:
0
9
0
0
9
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _