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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WRN
All Species:
25.76
Human Site:
Y636
Identified Species:
51.52
UniProt:
Q14191
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14191
NP_000544.2
1432
162495
Y636
T
D
I
K
L
G
K
Y
R
I
V
Y
V
T
P
Chimpanzee
Pan troglodytes
XP_528104
1432
162383
Y636
T
D
I
K
L
G
K
Y
R
I
V
Y
V
T
P
Rhesus Macaque
Macaca mulatta
XP_001085031
1432
162219
Y635
T
D
I
K
L
G
K
Y
R
I
V
Y
I
T
P
Dog
Lupus familis
XP_539984
1680
188955
Y832
E
D
I
K
L
G
K
Y
R
I
V
Y
I
T
P
Cat
Felis silvestris
Mouse
Mus musculus
O09053
1401
157269
Y600
G
D
V
K
L
G
K
Y
R
V
I
Y
I
T
P
Rat
Rattus norvegicus
XP_001059940
1400
157256
Y600
G
D
I
K
L
G
R
Y
R
I
I
Y
I
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508312
1813
203868
Y990
E
G
I
K
A
G
N
Y
R
V
V
F
L
T
P
Chicken
Gallus gallus
Q9I920
1142
126164
K387
S
H
S
E
E
M
L
K
I
F
H
R
K
F
G
Frog
Xenopus laevis
O93530
1436
161833
M577
Q
D
V
K
D
G
K
M
R
V
I
Y
M
T
P
Zebra Danio
Brachydanio rerio
XP_697980
1361
152386
F531
E
Q
V
K
R
G
D
F
R
V
V
Y
M
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19546
1056
118504
S301
A
V
K
L
D
G
H
S
T
Q
I
E
W
D
Q
Sea Urchin
Strong. purpuratus
XP_001184484
1274
143807
C519
R
I
A
N
I
K
A
C
Y
L
G
S
A
Q
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
94.1
64.5
N.A.
70.2
69.5
N.A.
41.7
22.9
52.1
45.8
N.A.
N.A.
N.A.
25.4
20.3
Protein Similarity:
100
99.3
97.2
72.6
N.A.
81.8
81.2
N.A.
56.5
38.3
70
63.7
N.A.
N.A.
N.A.
41.8
38.8
P-Site Identity:
100
100
93.3
86.6
N.A.
66.6
73.3
N.A.
53.3
0
53.3
46.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
73.3
13.3
80
73.3
N.A.
N.A.
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
9
0
9
0
0
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
59
0
0
17
0
9
0
0
0
0
0
0
9
0
% D
% Glu:
25
0
0
9
9
0
0
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
9
0
9
0
9
0
% F
% Gly:
17
9
0
0
0
84
0
0
0
0
9
0
0
0
9
% G
% His:
0
9
0
0
0
0
9
0
0
0
9
0
0
0
0
% H
% Ile:
0
9
50
0
9
0
0
0
9
42
34
0
34
0
0
% I
% Lys:
0
0
9
75
0
9
50
9
0
0
0
0
9
0
9
% K
% Leu:
0
0
0
9
50
0
9
0
0
9
0
0
9
0
0
% L
% Met:
0
0
0
0
0
9
0
9
0
0
0
0
17
0
0
% M
% Asn:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
75
% P
% Gln:
9
9
0
0
0
0
0
0
0
9
0
0
0
9
9
% Q
% Arg:
9
0
0
0
9
0
9
0
75
0
0
9
0
0
0
% R
% Ser:
9
0
9
0
0
0
0
9
0
0
0
9
0
0
0
% S
% Thr:
25
0
0
0
0
0
0
0
9
0
0
0
0
75
0
% T
% Val:
0
9
25
0
0
0
0
0
0
34
50
0
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
59
9
0
0
67
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _