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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WRN
All Species:
10.91
Human Site:
T486
Identified Species:
21.82
UniProt:
Q14191
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14191
NP_000544.2
1432
162495
T486
L
E
N
L
N
S
G
T
V
E
P
T
H
S
K
Chimpanzee
Pan troglodytes
XP_528104
1432
162383
T486
L
E
N
L
N
S
G
T
V
E
P
T
H
S
K
Rhesus Macaque
Macaca mulatta
XP_001085031
1432
162219
T486
L
E
N
L
N
S
G
T
V
E
P
T
H
S
K
Dog
Lupus familis
XP_539984
1680
188955
M684
L
E
N
L
N
T
G
M
A
D
P
I
H
S
K
Cat
Felis silvestris
Mouse
Mus musculus
O09053
1401
157269
M452
L
E
N
L
N
S
D
M
V
E
P
T
H
S
K
Rat
Rattus norvegicus
XP_001059940
1400
157256
V452
L
E
N
L
N
S
D
V
G
E
P
T
H
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508312
1813
203868
K842
L
E
E
I
D
S
G
K
R
K
Q
I
D
S
E
Chicken
Gallus gallus
Q9I920
1142
126164
V255
K
D
S
G
N
W
R
V
P
E
R
P
T
A
S
Frog
Xenopus laevis
O93530
1436
161833
S444
A
G
L
I
P
A
K
S
V
D
T
V
A
D
E
Zebra Danio
Brachydanio rerio
XP_697980
1361
152386
Q399
I
E
K
I
N
N
A
Q
M
P
Q
S
G
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19546
1056
118504
V169
D
P
E
F
M
D
S
V
L
D
N
Q
L
T
I
Sea Urchin
Strong. purpuratus
XP_001184484
1274
143807
L387
Y
D
T
P
S
L
A
L
K
I
G
H
S
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
94.1
64.5
N.A.
70.2
69.5
N.A.
41.7
22.9
52.1
45.8
N.A.
N.A.
N.A.
25.4
20.3
Protein Similarity:
100
99.3
97.2
72.6
N.A.
81.8
81.2
N.A.
56.5
38.3
70
63.7
N.A.
N.A.
N.A.
41.8
38.8
P-Site Identity:
100
100
100
66.6
N.A.
86.6
80
N.A.
33.3
13.3
6.6
13.3
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
100
80
N.A.
86.6
80
N.A.
60
33.3
40
60
N.A.
N.A.
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
9
17
0
9
0
0
0
9
17
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
17
0
0
9
9
17
0
0
25
0
0
9
9
0
% D
% Glu:
0
67
17
0
0
0
0
0
0
50
0
0
0
0
25
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
9
0
0
42
0
9
0
9
0
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
50
0
0
% H
% Ile:
9
0
0
25
0
0
0
0
0
9
0
17
0
0
9
% I
% Lys:
9
0
9
0
0
0
9
9
9
9
0
0
0
0
50
% K
% Leu:
59
0
9
50
0
9
0
9
9
0
0
0
9
9
0
% L
% Met:
0
0
0
0
9
0
0
17
9
0
0
0
0
0
9
% M
% Asn:
0
0
50
0
67
9
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
9
0
9
9
0
0
0
9
9
50
9
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
0
17
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
9
0
9
0
9
0
0
0
0
% R
% Ser:
0
0
9
0
9
50
9
9
0
0
0
9
9
59
9
% S
% Thr:
0
0
9
0
0
9
0
25
0
0
9
42
9
9
0
% T
% Val:
0
0
0
0
0
0
0
25
42
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _