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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WRN
All Species:
16.36
Human Site:
T346
Identified Species:
32.73
UniProt:
Q14191
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14191
NP_000544.2
1432
162495
T346
L
I
H
V
E
D
E
T
W
D
P
T
L
D
H
Chimpanzee
Pan troglodytes
XP_528104
1432
162383
T346
L
I
H
V
A
D
E
T
W
D
P
T
L
D
H
Rhesus Macaque
Macaca mulatta
XP_001085031
1432
162219
T346
F
I
N
V
E
D
E
T
W
D
P
T
L
D
H
Dog
Lupus familis
XP_539984
1680
188955
T570
F
P
K
V
K
D
E
T
W
D
T
T
F
D
N
Cat
Felis silvestris
Mouse
Mus musculus
O09053
1401
157269
P340
F
A
K
I
K
E
E
P
W
D
P
E
L
D
S
Rat
Rattus norvegicus
XP_001059940
1400
157256
A340
F
P
K
I
K
E
E
A
W
D
P
E
L
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508312
1813
203868
S729
F
C
K
F
T
E
E
S
K
D
A
A
G
D
E
Chicken
Gallus gallus
Q9I920
1142
126164
G154
P
G
T
P
L
C
S
G
P
G
Q
G
V
S
S
Frog
Xenopus laevis
O93530
1436
161833
S341
M
D
C
K
N
A
D
S
Q
N
N
K
D
I
D
Zebra Danio
Brachydanio rerio
XP_697980
1361
152386
D298
P
S
P
G
L
I
L
D
D
T
S
S
H
H
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19546
1056
118504
S68
S
F
D
D
F
V
P
S
Q
T
H
T
A
S
K
Sea Urchin
Strong. purpuratus
XP_001184484
1274
143807
S286
G
I
T
R
K
V
L
S
S
L
R
S
D
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
94.1
64.5
N.A.
70.2
69.5
N.A.
41.7
22.9
52.1
45.8
N.A.
N.A.
N.A.
25.4
20.3
Protein Similarity:
100
99.3
97.2
72.6
N.A.
81.8
81.2
N.A.
56.5
38.3
70
63.7
N.A.
N.A.
N.A.
41.8
38.8
P-Site Identity:
100
93.3
86.6
53.3
N.A.
40
40
N.A.
20
0
0
0
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
93.3
93.3
66.6
N.A.
60
60
N.A.
33.3
6.6
26.6
6.6
N.A.
N.A.
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
9
0
9
0
0
9
9
9
0
0
% A
% Cys:
0
9
9
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
9
9
0
34
9
9
9
59
0
0
17
59
9
% D
% Glu:
0
0
0
0
17
25
59
0
0
0
0
17
0
9
25
% E
% Phe:
42
9
0
9
9
0
0
0
0
0
0
0
9
0
0
% F
% Gly:
9
9
0
9
0
0
0
9
0
9
0
9
9
0
0
% G
% His:
0
0
17
0
0
0
0
0
0
0
9
0
9
9
25
% H
% Ile:
0
34
0
17
0
9
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
0
34
9
34
0
0
0
9
0
0
9
0
0
9
% K
% Leu:
17
0
0
0
17
0
17
0
0
9
0
0
42
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
9
0
0
0
0
9
9
0
0
0
9
% N
% Pro:
17
17
9
9
0
0
9
9
9
0
42
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
17
0
9
0
0
0
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
9
0
0
0
0
% R
% Ser:
9
9
0
0
0
0
9
34
9
0
9
17
0
17
25
% S
% Thr:
0
0
17
0
9
0
0
34
0
17
9
42
0
0
0
% T
% Val:
0
0
0
34
0
17
0
0
0
0
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _