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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WRN
All Species:
15.15
Human Site:
S312
Identified Species:
30.3
UniProt:
Q14191
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14191
NP_000544.2
1432
162495
S312
I
E
T
E
L
R
P
S
N
N
L
N
L
L
S
Chimpanzee
Pan troglodytes
XP_528104
1432
162383
S312
I
E
T
E
L
R
P
S
N
N
L
N
L
L
S
Rhesus Macaque
Macaca mulatta
XP_001085031
1432
162219
S312
I
E
T
E
L
R
P
S
N
N
L
N
L
L
S
Dog
Lupus familis
XP_539984
1680
188955
T537
E
A
E
L
R
H
S
T
N
V
H
L
L
S
L
Cat
Felis silvestris
Mouse
Mus musculus
O09053
1401
157269
G306
T
E
T
R
L
K
P
G
S
S
F
N
L
L
S
Rat
Rattus norvegicus
XP_001059940
1400
157256
G306
T
G
T
K
L
E
P
G
G
G
S
H
L
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508312
1813
203868
D698
S
E
T
R
T
N
N
D
L
S
M
S
S
L
E
Chicken
Gallus gallus
Q9I920
1142
126164
T126
A
D
S
G
A
L
N
T
N
S
V
N
G
P
R
Frog
Xenopus laevis
O93530
1436
161833
H306
K
A
E
G
N
G
L
H
F
Q
N
S
E
D
C
Zebra Danio
Brachydanio rerio
XP_697980
1361
152386
T270
D
D
L
S
Q
T
L
T
S
L
R
C
V
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19546
1056
118504
S40
E
T
E
P
E
S
D
S
D
K
P
T
V
T
S
Sea Urchin
Strong. purpuratus
XP_001184484
1274
143807
K258
N
A
D
G
E
P
S
K
K
R
Q
R
N
W
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
94.1
64.5
N.A.
70.2
69.5
N.A.
41.7
22.9
52.1
45.8
N.A.
N.A.
N.A.
25.4
20.3
Protein Similarity:
100
99.3
97.2
72.6
N.A.
81.8
81.2
N.A.
56.5
38.3
70
63.7
N.A.
N.A.
N.A.
41.8
38.8
P-Site Identity:
100
100
100
13.3
N.A.
53.3
40
N.A.
20
13.3
0
13.3
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
100
100
100
20
N.A.
73.3
53.3
N.A.
40
46.6
6.6
40
N.A.
N.A.
N.A.
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
25
0
0
9
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% C
% Asp:
9
17
9
0
0
0
9
9
9
0
0
0
0
9
0
% D
% Glu:
17
42
25
25
17
9
0
0
0
0
0
0
9
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% F
% Gly:
0
9
0
25
0
9
0
17
9
9
0
0
9
0
0
% G
% His:
0
0
0
0
0
9
0
9
0
0
9
9
0
0
0
% H
% Ile:
25
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
9
0
9
0
9
9
9
0
0
0
0
0
% K
% Leu:
0
0
9
9
42
9
17
0
9
9
25
9
50
59
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
9
0
0
0
9
9
17
0
42
25
9
42
9
0
0
% N
% Pro:
0
0
0
9
0
9
42
0
0
0
9
0
0
9
0
% P
% Gln:
0
0
0
0
9
0
0
0
0
9
9
0
0
0
0
% Q
% Arg:
0
0
0
17
9
25
0
0
0
9
9
9
0
0
17
% R
% Ser:
9
0
9
9
0
9
17
34
17
25
9
17
9
9
59
% S
% Thr:
17
9
50
0
9
9
0
25
0
0
0
9
0
9
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
9
0
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _