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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WRN
All Species:
13.33
Human Site:
S1378
Identified Species:
26.67
UniProt:
Q14191
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14191
NP_000544.2
1432
162495
S1378
K
R
R
C
F
P
G
S
E
E
I
C
S
S
S
Chimpanzee
Pan troglodytes
XP_528104
1432
162383
S1378
K
R
R
C
F
P
G
S
E
E
I
C
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001085031
1432
162219
S1378
K
R
R
Y
F
P
S
S
E
E
I
S
S
S
S
Dog
Lupus familis
XP_539984
1680
188955
F1576
A
S
N
R
K
R
Y
F
P
N
S
E
E
N
C
Cat
Felis silvestris
Mouse
Mus musculus
O09053
1401
157269
S1343
R
K
R
R
F
P
S
S
A
E
S
C
E
S
C
Rat
Rattus norvegicus
XP_001059940
1400
157256
P1343
R
K
R
C
L
P
S
P
A
E
S
C
G
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508312
1813
203868
C1728
Y
T
K
Q
S
A
L
C
K
S
K
E
K
Q
S
Chicken
Gallus gallus
Q9I920
1142
126164
S1089
G
G
S
Q
Q
F
Y
S
K
G
A
R
Y
R
R
Frog
Xenopus laevis
O93530
1436
161833
T1326
T
Q
K
T
L
I
Q
T
E
E
N
P
K
N
V
Zebra Danio
Brachydanio rerio
XP_697980
1361
152386
W1308
T
T
R
H
E
I
S
W
I
E
P
L
D
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19546
1056
118504
R1003
F
N
Q
L
K
L
I
R
A
I
L
I
Y
E
Y
Sea Urchin
Strong. purpuratus
XP_001184484
1274
143807
L1221
V
Q
Y
S
S
P
Y
L
G
C
E
W
L
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
94.1
64.5
N.A.
70.2
69.5
N.A.
41.7
22.9
52.1
45.8
N.A.
N.A.
N.A.
25.4
20.3
Protein Similarity:
100
99.3
97.2
72.6
N.A.
81.8
81.2
N.A.
56.5
38.3
70
63.7
N.A.
N.A.
N.A.
41.8
38.8
P-Site Identity:
100
100
80
0
N.A.
46.6
40
N.A.
6.6
6.6
13.3
20
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
80
6.6
N.A.
60
53.3
N.A.
20
13.3
40
20
N.A.
N.A.
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
9
0
0
25
0
9
0
0
0
0
% A
% Cys:
0
0
0
25
0
0
0
9
0
9
0
34
0
0
17
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% D
% Glu:
0
0
0
0
9
0
0
0
34
59
9
17
17
9
0
% E
% Phe:
9
0
0
0
34
9
0
9
0
0
0
0
0
0
9
% F
% Gly:
9
9
0
0
0
0
17
0
9
9
0
0
9
0
0
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
17
9
0
9
9
25
9
0
0
0
% I
% Lys:
25
17
17
0
17
0
0
0
17
0
9
0
17
9
0
% K
% Leu:
0
0
0
9
17
9
9
9
0
0
9
9
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
9
9
0
0
0
0
0
0
9
9
0
0
17
0
% N
% Pro:
0
0
0
0
0
50
0
9
9
0
9
9
0
0
0
% P
% Gln:
0
17
9
17
9
0
9
0
0
0
0
0
0
9
0
% Q
% Arg:
17
25
50
17
0
9
0
9
0
0
0
9
0
9
9
% R
% Ser:
0
9
9
9
17
0
34
42
0
9
25
9
25
42
42
% S
% Thr:
17
17
0
9
0
0
0
9
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% W
% Tyr:
9
0
9
9
0
0
25
0
0
0
0
0
17
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _