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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WRN All Species: 12.42
Human Site: S1083 Identified Species: 24.85
UniProt: Q14191 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14191 NP_000544.2 1432 162495 S1083 L P S S K T V S S G T K E H C
Chimpanzee Pan troglodytes XP_528104 1432 162383 S1083 L P S S K T V S S G T K E H C
Rhesus Macaque Macaca mulatta XP_001085031 1432 162219 S1083 L P S S R T V S S G T K E H S
Dog Lupus familis XP_539984 1680 188955 P1281 L P S S K T V P P G A E Q H S
Cat Felis silvestris
Mouse Mus musculus O09053 1401 157269 V1048 L L P S S N P V S P E T T Q H
Rat Rattus norvegicus XP_001059940 1400 157256 V1048 L L S S S N P V S S E T K P H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508312 1813 203868 S1438 L P S A T T T S S D K E Q H F
Chicken Gallus gallus Q9I920 1142 126164 K812 R N V T D E V K S I I R F V Q
Frog Xenopus laevis O93530 1436 161833 S1031 S S A Q A H S S M V P H A S S
Zebra Danio Brachydanio rerio XP_697980 1361 152386 P1031 A P R R K A D P A Q V E P T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19546 1056 118504 G726 C I T L S E L G E R W L L T G
Sea Urchin Strong. purpuratus XP_001184484 1274 143807 M944 G Y T M Y R S M E S G T N A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 94.1 64.5 N.A. 70.2 69.5 N.A. 41.7 22.9 52.1 45.8 N.A. N.A. N.A. 25.4 20.3
Protein Similarity: 100 99.3 97.2 72.6 N.A. 81.8 81.2 N.A. 56.5 38.3 70 63.7 N.A. N.A. N.A. 41.8 38.8
P-Site Identity: 100 100 86.6 60 N.A. 20 26.6 N.A. 46.6 13.3 6.6 13.3 N.A. N.A. N.A. 0 0
P-Site Similarity: 100 100 93.3 73.3 N.A. 20 33.3 N.A. 66.6 26.6 13.3 26.6 N.A. N.A. N.A. 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 9 9 9 0 0 9 0 9 0 9 9 0 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 17 % C
% Asp: 0 0 0 0 9 0 9 0 0 9 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 17 0 0 17 0 17 25 25 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 9 % F
% Gly: 9 0 0 0 0 0 0 9 0 34 9 0 0 0 9 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 9 0 42 17 % H
% Ile: 0 9 0 0 0 0 0 0 0 9 9 0 0 0 0 % I
% Lys: 0 0 0 0 34 0 0 9 0 0 9 25 9 0 0 % K
% Leu: 59 17 0 9 0 0 9 0 0 0 0 9 9 0 0 % L
% Met: 0 0 0 9 0 0 0 9 9 0 0 0 0 0 0 % M
% Asn: 0 9 0 0 0 17 0 0 0 0 0 0 9 0 0 % N
% Pro: 0 50 9 0 0 0 17 17 9 9 9 0 9 9 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 9 0 0 17 9 9 % Q
% Arg: 9 0 9 9 9 9 0 0 0 9 0 9 0 0 0 % R
% Ser: 9 9 50 50 25 0 17 42 59 17 0 0 0 9 34 % S
% Thr: 0 0 17 9 9 42 9 0 0 0 25 25 9 17 0 % T
% Val: 0 0 9 0 0 0 42 17 0 9 9 0 0 9 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % W
% Tyr: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _