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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM2
All Species:
2.73
Human Site:
Y524
Identified Species:
5.45
UniProt:
Q14190
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14190
NP_005060.1
667
73219
Y524
R
H
S
L
V
P
S
Y
E
A
P
A
A
A
V
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
N608
K
H
S
L
C
F
A
N
Y
Q
Q
P
P
P
T
Rhesus Macaque
Macaca mulatta
XP_001085660
634
69808
R517
F
P
S
C
G
H
Y
R
E
E
P
A
L
G
P
Dog
Lupus familis
XP_539058
766
85506
Y609
H
S
L
C
F
A
N
Y
Q
Q
P
P
P
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61079
657
72494
N524
A
R
H
G
L
V
P
N
Y
E
A
P
S
A
A
Rat
Rattus norvegicus
O35800
825
92301
G597
P
S
V
S
T
V
T
G
F
Q
Q
T
Q
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512322
938
100601
P811
G
A
R
L
G
L
A
P
S
Y
Q
A
A
P
P
Chicken
Gallus gallus
Q9YIB9
811
90524
I596
Q
N
A
A
T
I
T
I
L
Q
Q
T
Q
T
P
Frog
Xenopus laevis
Q9I8A9
805
90946
I562
L
E
M
L
A
P
Y
I
P
M
D
D
D
F
Q
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
Q522
I
A
S
I
H
S
L
Q
V
R
G
H
W
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
S577
S
S
A
S
A
S
S
S
G
V
Y
S
T
E
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
V550
C
C
N
D
T
S
D
V
R
H
L
E
T
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.9
81.8
52.2
N.A.
90.2
28.7
N.A.
47
29.3
23.7
52.7
N.A.
41.4
N.A.
N.A.
41.4
Protein Similarity:
100
62.5
84.2
61.3
N.A.
92.3
43.8
N.A.
52.5
45.8
40.5
62
N.A.
51.3
N.A.
N.A.
55.2
P-Site Identity:
100
20
26.6
20
N.A.
6.6
0
N.A.
20
0
13.3
6.6
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
33.3
26.6
33.3
N.A.
20
6.6
N.A.
26.6
26.6
13.3
13.3
N.A.
26.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
17
9
17
9
17
0
0
9
9
25
17
25
9
% A
% Cys:
9
9
0
17
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
9
0
0
0
9
9
9
9
0
% D
% Glu:
0
9
0
0
0
0
0
0
17
17
0
9
0
9
9
% E
% Phe:
9
0
0
0
9
9
0
0
9
0
0
0
0
9
0
% F
% Gly:
9
0
0
9
17
0
0
9
9
0
9
0
0
9
9
% G
% His:
9
17
9
0
9
9
0
0
0
9
0
9
0
0
0
% H
% Ile:
9
0
0
9
0
9
0
17
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
9
34
9
9
9
0
9
0
9
0
9
17
0
% L
% Met:
0
0
9
0
0
0
0
0
0
9
0
0
0
0
9
% M
% Asn:
0
9
9
0
0
0
9
17
0
0
0
0
0
0
0
% N
% Pro:
9
9
0
0
0
17
9
9
9
0
25
25
17
17
25
% P
% Gln:
9
0
0
0
0
0
0
9
9
34
34
0
17
0
17
% Q
% Arg:
9
9
9
0
0
0
0
9
9
9
0
0
0
0
0
% R
% Ser:
9
25
34
17
0
25
17
9
9
0
0
9
9
0
9
% S
% Thr:
0
0
0
0
25
0
17
0
0
0
0
17
17
9
9
% T
% Val:
0
0
9
0
9
17
0
9
9
9
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
17
17
17
9
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _