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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM2
All Species:
41.82
Human Site:
Y255
Identified Species:
83.64
UniProt:
Q14190
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14190
NP_005060.1
667
73219
Y255
R
V
T
E
V
T
G
Y
E
P
Q
D
L
I
E
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
Y255
R
V
A
E
L
T
G
Y
E
P
Q
D
L
I
E
Rhesus Macaque
Macaca mulatta
XP_001085660
634
69808
V249
L
I
F
L
D
S
R
V
T
E
V
T
G
Y
E
Dog
Lupus familis
XP_539058
766
85506
Y255
R
V
A
E
L
T
G
Y
E
P
Q
D
L
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61079
657
72494
Y255
R
V
T
E
L
T
G
Y
E
P
Q
D
L
I
E
Rat
Rattus norvegicus
O35800
825
92301
Y265
R
I
T
E
L
M
G
Y
E
P
E
E
L
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512322
938
100601
Y508
R
V
T
E
L
T
G
Y
E
P
Q
D
L
I
E
Chicken
Gallus gallus
Q9YIB9
811
90524
Y265
R
I
T
E
L
M
G
Y
E
P
E
E
L
L
G
Frog
Xenopus laevis
Q9I8A9
805
90946
Y266
R
V
T
E
L
V
G
Y
E
P
D
E
L
L
G
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
Y255
R
V
A
E
L
T
G
Y
E
P
Q
D
L
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
Y303
R
V
S
Q
L
T
G
Y
E
P
Q
D
L
I
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
Y254
K
V
A
V
L
T
G
Y
E
P
Q
D
L
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.9
81.8
52.2
N.A.
90.2
28.7
N.A.
47
29.3
23.7
52.7
N.A.
41.4
N.A.
N.A.
41.4
Protein Similarity:
100
62.5
84.2
61.3
N.A.
92.3
43.8
N.A.
52.5
45.8
40.5
62
N.A.
51.3
N.A.
N.A.
55.2
P-Site Identity:
100
86.6
6.6
86.6
N.A.
93.3
53.3
N.A.
93.3
53.3
60
86.6
N.A.
80
N.A.
N.A.
73.3
P-Site Similarity:
100
93.3
20
93.3
N.A.
100
86.6
N.A.
100
86.6
80
93.3
N.A.
100
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
0
0
0
9
67
0
0
0
% D
% Glu:
0
0
0
75
0
0
0
0
92
9
17
25
0
0
75
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
92
0
0
0
0
0
9
0
25
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
25
0
0
0
0
0
0
0
0
0
0
0
67
0
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
9
84
0
0
0
0
0
0
0
92
25
0
% L
% Met:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
92
0
0
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
67
0
0
0
0
% Q
% Arg:
84
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
0
0
9
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
50
0
0
67
0
0
9
0
0
9
0
0
0
% T
% Val:
0
75
0
9
9
9
0
9
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _