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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM2
All Species:
3.64
Human Site:
T646
Identified Species:
7.27
UniProt:
Q14190
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14190
NP_005060.1
667
73219
T646
R
H
P
S
P
A
A
T
S
P
P
G
A
P
L
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
L745
H
F
D
V
T
S
H
L
R
M
Q
P
D
P
A
Rhesus Macaque
Macaca mulatta
XP_001085660
634
69808
A613
R
H
P
S
P
A
A
A
S
P
A
G
T
P
L
Dog
Lupus familis
XP_539058
766
85506
L745
H
F
D
V
T
S
H
L
R
M
Q
P
D
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61079
657
72494
A636
R
H
P
G
P
V
A
A
S
A
P
G
A
P
R
Rat
Rattus norvegicus
O35800
825
92301
S789
L
G
Q
S
M
D
E
S
G
L
P
Q
L
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512322
938
100601
A912
G
G
P
G
P
Q
A
A
G
E
R
G
A
E
G
Chicken
Gallus gallus
Q9YIB9
811
90524
V787
L
T
S
Y
D
C
E
V
N
A
P
I
Q
G
N
Frog
Xenopus laevis
Q9I8A9
805
90946
S754
Q
R
T
I
L
L
L
S
T
D
M
A
S
Q
L
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
H724
S
H
Y
D
M
T
T
H
L
R
K
A
E
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
Q674
F
S
D
N
S
S
Q
Q
H
Q
H
Q
Q
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
T738
S
P
P
S
I
N
G
T
S
R
L
T
D
Y
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.9
81.8
52.2
N.A.
90.2
28.7
N.A.
47
29.3
23.7
52.7
N.A.
41.4
N.A.
N.A.
41.4
Protein Similarity:
100
62.5
84.2
61.3
N.A.
92.3
43.8
N.A.
52.5
45.8
40.5
62
N.A.
51.3
N.A.
N.A.
55.2
P-Site Identity:
100
6.6
80
6.6
N.A.
66.6
13.3
N.A.
33.3
6.6
6.6
6.6
N.A.
0
N.A.
N.A.
26.6
P-Site Similarity:
100
13.3
80
13.3
N.A.
66.6
20
N.A.
33.3
13.3
33.3
6.6
N.A.
13.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
17
34
25
0
17
9
17
25
0
25
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
25
9
9
9
0
0
0
9
0
0
25
0
0
% D
% Glu:
0
0
0
0
0
0
17
0
0
9
0
0
9
9
0
% E
% Phe:
9
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
17
0
17
0
0
9
0
17
0
0
34
0
9
9
% G
% His:
17
34
0
0
0
0
17
9
9
0
9
0
0
0
0
% H
% Ile:
0
0
0
9
9
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% K
% Leu:
17
0
0
0
9
9
9
17
9
9
9
0
9
0
25
% L
% Met:
0
0
0
0
17
0
0
0
0
17
9
0
0
0
0
% M
% Asn:
0
0
0
9
0
9
0
0
9
0
0
0
0
0
9
% N
% Pro:
0
9
42
0
34
0
0
0
0
17
34
17
0
42
0
% P
% Gln:
9
0
9
0
0
9
9
9
0
9
17
17
17
25
9
% Q
% Arg:
25
9
0
0
0
0
0
0
17
17
9
0
0
0
9
% R
% Ser:
17
9
9
34
9
25
0
17
34
0
0
0
9
0
9
% S
% Thr:
0
9
9
0
17
9
9
17
9
0
0
9
9
9
0
% T
% Val:
0
0
0
17
0
9
0
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
9
0
0
0
0
0
0
0
0
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _