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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM2
All Species:
9.7
Human Site:
S451
Identified Species:
19.39
UniProt:
Q14190
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14190
NP_005060.1
667
73219
S451
Y
G
H
F
P
L
D
S
H
V
F
S
S
K
K
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
S535
W
D
E
D
S
V
V
S
S
P
D
P
G
S
A
Rhesus Macaque
Macaca mulatta
XP_001085660
634
69808
A444
N
P
R
Q
R
V
E
A
R
P
R
L
R
R
G
Dog
Lupus familis
XP_539058
766
85506
S536
D
E
D
S
V
V
S
S
P
D
P
G
S
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61079
657
72494
S451
Y
G
H
F
P
L
D
S
H
V
F
S
S
K
K
Rat
Rattus norvegicus
O35800
825
92301
S524
E
Y
C
F
D
V
D
S
D
M
V
N
V
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512322
938
100601
P738
Y
G
P
F
P
V
D
P
H
V
L
G
G
K
K
Chicken
Gallus gallus
Q9YIB9
811
90524
N523
D
Y
C
F
D
V
D
N
D
M
A
N
E
F
K
Frog
Xenopus laevis
Q9I8A9
805
90946
S489
T
C
A
S
I
H
H
S
T
A
I
Q
A
R
Q
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
D449
Y
G
L
P
L
T
E
D
H
H
T
S
N
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
P504
P
A
V
T
P
V
P
P
T
N
N
S
S
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
N477
E
A
Y
A
H
C
V
N
D
R
I
S
S
Y
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.9
81.8
52.2
N.A.
90.2
28.7
N.A.
47
29.3
23.7
52.7
N.A.
41.4
N.A.
N.A.
41.4
Protein Similarity:
100
62.5
84.2
61.3
N.A.
92.3
43.8
N.A.
52.5
45.8
40.5
62
N.A.
51.3
N.A.
N.A.
55.2
P-Site Identity:
100
6.6
0
13.3
N.A.
100
26.6
N.A.
60
20
6.6
26.6
N.A.
20
N.A.
N.A.
13.3
P-Site Similarity:
100
20
26.6
20
N.A.
100
46.6
N.A.
66.6
46.6
26.6
46.6
N.A.
26.6
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
9
9
0
0
0
9
0
9
9
0
9
9
9
% A
% Cys:
0
9
17
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
9
9
9
17
0
42
9
25
9
9
0
0
0
0
% D
% Glu:
17
9
9
0
0
0
17
0
0
0
0
0
9
9
0
% E
% Phe:
0
0
0
42
0
0
0
0
0
0
17
0
0
17
0
% F
% Gly:
0
34
0
0
0
0
0
0
0
0
0
17
17
0
9
% G
% His:
0
0
17
0
9
9
9
0
34
9
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
0
17
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
42
% K
% Leu:
0
0
9
0
9
17
0
0
0
0
9
9
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
17
0
9
9
17
9
0
0
% N
% Pro:
9
9
9
9
34
0
9
17
9
17
9
9
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
9
% Q
% Arg:
0
0
9
0
9
0
0
0
9
9
9
0
9
17
9
% R
% Ser:
0
0
0
17
9
0
9
50
9
0
0
42
42
17
17
% S
% Thr:
9
0
0
9
0
9
0
0
17
0
9
0
0
0
0
% T
% Val:
0
0
9
0
9
59
17
0
0
25
9
0
9
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
34
17
9
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _