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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOB2 All Species: 9.09
Human Site: T224 Identified Species: 20
UniProt: Q14106 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14106 NP_057356.1 344 36632 T224 P R M A R S P T N S L L K H K
Chimpanzee Pan troglodytes XP_001169370 344 36584 T224 P R M A R S P T N S L L K H K
Rhesus Macaque Macaca mulatta XP_001104257 335 35811 Q215 A G G Q Q P P Q Q P R M A R S
Dog Lupus familis XP_849289 316 34141 R199 K K G G G A P R L A R S P T N
Cat Felis silvestris
Mouse Mus musculus Q9JM55 345 36780 T225 P R M A R S P T K N L L K H K
Rat Rattus norvegicus Q8R5K6 365 40443 P246 Q Q Q P Q P Q P Q Q P P S Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506228 329 34806 Q209 G G E G A A P Q P R L A R S P
Chicken Gallus gallus NP_001012552 340 36273 H223 P T T N L L K H K G L S L S M
Frog Xenopus laevis P40745 233 26927 S116 N D P F T I A S F K G K D G Y
Zebra Danio Brachydanio rerio NP_998139 322 35292 G203 M K N S G R N G G K V A R T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573104 564 59093 A232 G A T A N A A A A A F M Q R G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 96.8 87.5 N.A. 89.5 50.6 N.A. 84.3 82.8 21.7 61 N.A. 29.6 N.A. N.A. N.A.
Protein Similarity: 100 99.7 96.8 90.1 N.A. 92.7 64.1 N.A. 87.2 86.9 37.2 72.9 N.A. 43.2 N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 6.6 N.A. 86.6 0 N.A. 13.3 13.3 0 0 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 20 26.6 N.A. 93.3 13.3 N.A. 26.6 13.3 6.6 26.6 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 37 10 28 19 10 10 19 0 19 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 0 0 10 0 10 0 0 0 0 % F
% Gly: 19 19 19 19 19 0 0 10 10 10 10 0 0 10 10 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 28 0 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 19 0 0 0 0 10 0 19 19 0 10 28 0 28 % K
% Leu: 0 0 0 0 10 10 0 0 10 0 46 28 10 0 0 % L
% Met: 10 0 28 0 0 0 0 0 0 0 0 19 0 0 10 % M
% Asn: 10 0 10 10 10 0 10 0 19 10 0 0 0 0 10 % N
% Pro: 37 0 10 10 0 19 55 10 10 10 10 10 10 0 19 % P
% Gln: 10 10 10 10 19 0 10 19 19 10 0 0 10 10 0 % Q
% Arg: 0 28 0 0 28 10 0 10 0 10 19 0 19 19 0 % R
% Ser: 0 0 0 10 0 28 0 10 0 19 0 19 10 19 19 % S
% Thr: 0 10 19 0 10 0 0 28 0 0 0 0 0 19 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _