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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RUNX3 All Species: 5.15
Human Site: S218 Identified Species: 10.3
UniProt: Q13761 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13761 NP_001026850.1 415 44356 S218 S T P S P R G S L S T T S H F
Chimpanzee Pan troglodytes XP_001168112 361 38974 L165 T P S P R G S L S T T S H F S
Rhesus Macaque Macaca mulatta XP_001113682 501 52667 Y304 A P L G V R Q Y D N H F T D V
Dog Lupus familis XP_544492 414 44288 G218 C T P S S P G G P T L P P E A
Cat Felis silvestris
Mouse Mus musculus Q64131 409 43610 P213 V T P S T P S P R G S L S T T
Rat Rattus norvegicus Q63046 450 48538 N227 P N P R A S L N H S T A F N P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232978 334 36473 T138 S M R V T P T T P S P R G S I
Frog Xenopus laevis Q6PF39 462 50351 S265 Q S Y Q Y L G S I A T Q S V H
Zebra Danio Brachydanio rerio NP_571679 424 45996 S222 Q T H Y S P S S T T Q I P G L
Tiger Blowfish Takifugu rubipres NP_001092121 407 44638 P210 I G T A N N N P R P I H Q A H
Fruit Fly Dros. melanogaster Q9W349 826 84703 A470 N A V A A A A A A V A V T P T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q9ATN1 302 31144 P106 K Y G G A I S P F G N A A C A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.9 63 48.6 N.A. 91.5 59.5 N.A. N.A. 68.9 56.9 68.1 67.9 23.3 N.A. N.A. N.A.
Protein Similarity: 100 86.9 68.2 56.1 N.A. 94.6 70.4 N.A. N.A. 74.2 69 75.2 77.3 33.1 N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 26.6 N.A. 26.6 20 N.A. N.A. 13.3 26.6 13.3 0 0 N.A. N.A. N.A.
P-Site Similarity: 100 26.6 26.6 33.3 N.A. 33.3 33.3 N.A. N.A. 20 46.6 20 6.6 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. 20 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 30.6 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 0 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 6.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 17 25 9 9 9 9 9 9 17 9 9 17 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 9 9 9 9 % F
% Gly: 0 9 9 17 0 9 25 9 0 17 0 0 9 9 0 % G
% His: 0 0 9 0 0 0 0 0 9 0 9 9 9 9 17 % H
% Ile: 9 0 0 0 0 9 0 0 9 0 9 9 0 0 9 % I
% Lys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 9 0 0 9 9 9 9 0 9 9 0 0 9 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 9 0 0 9 9 9 9 0 9 9 0 0 9 0 % N
% Pro: 9 17 34 9 9 34 0 25 17 9 9 9 17 9 9 % P
% Gln: 17 0 0 9 0 0 9 0 0 0 9 9 9 0 0 % Q
% Arg: 0 0 9 9 9 17 0 0 17 0 0 9 0 0 0 % R
% Ser: 17 9 9 25 17 9 34 25 9 25 9 9 25 9 9 % S
% Thr: 9 34 9 0 17 0 9 9 9 25 34 9 17 9 17 % T
% Val: 9 0 9 9 9 0 0 0 0 9 0 9 0 9 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 9 9 9 0 0 9 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _