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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK1A All Species: 23.94
Human Site: Y633 Identified Species: 58.52
UniProt: Q13627 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13627 NP_001387.2 763 85584 Y633 N R T R P R V Y N S P T N S S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001083622 763 85491 Y633 N R T R P R V Y N S P T N S S
Dog Lupus familis XP_849580 654 74158 G525 S S G T S N S G R A R S D P T
Cat Felis silvestris
Mouse Mus musculus Q61214 763 85475 Y633 N R T R P R V Y N S P T N S S
Rat Rattus norvegicus Q63470 763 85522 Y633 N R T R P R V Y N S P T N S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509695 797 89233 Y667 S R T R P R V Y N S P T N S S
Chicken Gallus gallus Q5ZIU3 526 59419 D397 C T I T T L S D G S I I L N G
Frog Xenopus laevis Q2TAE3 750 84138 Y620 N R T R T R I Y N S P S T S S
Zebra Danio Brachydanio rerio XP_001923159 727 81338 S597 P R P R L Y N S P T N S A S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49657 908 95884 N656 G S T G C H N N N S N S S N N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 85.1 N.A. 99.2 99.6 N.A. 94.4 26.7 91.4 78.7 N.A. 47.7 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 99.8 85.5 N.A. 99.4 99.7 N.A. 95.2 39.9 94.2 84.2 N.A. 60.2 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 100 0 N.A. 100 100 N.A. 93.3 6.6 73.3 20 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 100 33.3 N.A. 100 100 N.A. 100 13.3 86.6 40 N.A. 46.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 10 0 0 10 0 0 % A
% Cys: 10 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 10 10 0 0 0 10 10 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 10 0 0 0 10 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 10 10 0 0 0 0 0 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 50 0 0 0 0 10 20 10 70 0 20 0 50 20 10 % N
% Pro: 10 0 10 0 50 0 0 0 10 0 60 0 0 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 70 0 70 0 60 0 0 10 0 10 0 0 0 0 % R
% Ser: 20 20 0 0 10 0 20 10 0 80 0 40 10 70 60 % S
% Thr: 0 10 70 20 20 0 0 0 0 10 0 50 10 0 20 % T
% Val: 0 0 0 0 0 0 50 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _