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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK1A
All Species:
18.18
Human Site:
Y145
Identified Species:
44.44
UniProt:
Q13627
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13627
NP_001387.2
763
85584
Y145
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083622
763
85491
Y145
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
Dog
Lupus familis
XP_849580
654
74158
K105
V
D
L
I
K
T
Y
K
H
I
N
E
V
Y
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61214
763
85475
Y145
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
Rat
Rattus norvegicus
Q63470
763
85522
Y145
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509695
797
89233
Y179
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
Chicken
Gallus gallus
Q5ZIU3
526
59419
Frog
Xenopus laevis
Q2TAE3
750
84138
I153
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
Zebra Danio
Brachydanio rerio
XP_001923159
727
81338
V144
K
G
S
F
G
Q
V
V
K
A
Y
D
R
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49657
908
95884
H150
D
G
Y
D
D
D
N
H
D
Y
I
I
K
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
85.1
N.A.
99.2
99.6
N.A.
94.4
26.7
91.4
78.7
N.A.
47.7
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
99.8
85.5
N.A.
99.4
99.7
N.A.
95.2
39.9
94.2
84.2
N.A.
60.2
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
0
N.A.
100
100
N.A.
100
0
20
6.6
N.A.
86.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
0
N.A.
100
100
N.A.
100
0
33.3
13.3
N.A.
100
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
10
0
70
60
60
0
0
70
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
10
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
0
0
10
0
0
0
0
0
0
0
10
0
70
% G
% His:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
0
10
60
20
0
0
0
% I
% Lys:
20
0
0
0
10
0
0
10
10
0
0
0
60
10
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
60
0
0
0
10
0
0
60
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% R
% Ser:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% T
% Val:
10
0
0
0
0
0
10
10
0
0
0
50
10
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
60
0
0
10
10
50
0
60
10
0
0
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _