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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AQP6
All Species:
10
Human Site:
S228
Identified Species:
20
UniProt:
Q13520
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13520
NP_001643.2
282
29370
S228
L
M
G
A
L
L
A
S
L
I
Y
N
F
V
L
Chimpanzee
Pan troglodytes
XP_001157230
282
29322
S228
L
M
G
A
L
L
A
S
L
I
Y
N
F
V
L
Rhesus Macaque
Macaca mulatta
XP_001110572
271
28897
L218
G
A
I
L
G
S
L
L
Y
N
Y
V
L
F
P
Dog
Lupus familis
XP_850452
271
28631
Y218
A
V
L
A
S
L
I
Y
N
F
I
L
F
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8C4A0
293
30690
S225
L
T
G
A
V
L
A
S
L
I
Y
N
F
I
L
Rat
Rattus norvegicus
Q9WTY0
276
28841
L223
G
P
L
T
G
A
V
L
A
S
L
I
Y
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518393
255
27145
I202
G
A
I
L
G
S
L
I
Y
N
Y
L
L
F
P
Chicken
Gallus gallus
P28238
262
27053
L209
W
V
F
W
A
G
P
L
L
G
A
A
L
A
A
Frog
Xenopus laevis
NP_001079331
273
29418
N220
I
M
A
S
L
F
Y
N
Y
I
F
F
P
H
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V5Z7
245
25557
N192
K
L
S
G
A
S
M
N
P
A
R
S
F
G
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q84RL6
248
25114
M195
G
P
F
S
G
G
S
M
N
P
A
R
S
F
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZVX8
278
29482
R222
G
T
G
I
N
P
A
R
S
F
G
A
A
V
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
54.6
76.5
N.A.
71.6
76.9
N.A.
50.3
46
51.7
N.A.
N.A.
36.1
N.A.
N.A.
N.A.
Protein Similarity:
100
98.9
66.6
85.1
N.A.
78.5
84
N.A.
59.9
59.9
67
N.A.
N.A.
49.6
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
20
N.A.
80
0
N.A.
6.6
6.6
20
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
26.6
N.A.
93.3
6.6
N.A.
6.6
13.3
46.6
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
32.2
N.A.
37.9
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
9
34
17
9
34
0
9
9
17
17
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
17
0
0
9
0
0
0
17
9
9
42
25
9
% F
% Gly:
42
0
34
9
34
17
0
0
0
9
9
0
0
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
9
0
17
9
0
0
9
9
0
34
9
9
0
9
9
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% K
% Leu:
25
9
17
17
25
34
17
25
34
0
9
17
25
0
25
% L
% Met:
0
25
0
0
0
0
9
9
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
17
17
17
0
25
0
9
0
% N
% Pro:
0
17
0
0
0
9
9
0
9
9
0
0
9
9
25
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
9
9
0
0
0
% R
% Ser:
0
0
9
17
9
25
9
25
9
9
0
9
9
0
0
% S
% Thr:
0
17
0
9
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
17
0
0
9
0
9
0
0
0
0
9
0
25
0
% V
% Trp:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
9
25
0
42
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _