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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PICALM
All Species:
29.39
Human Site:
S248
Identified Species:
53.89
UniProt:
Q13492
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13492
NP_001008660.1
652
70755
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Chimpanzee
Pan troglodytes
XP_508908
793
85002
S396
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Rhesus Macaque
Macaca mulatta
XP_001085480
907
92424
S248
L
T
R
M
T
R
V
S
E
F
L
K
V
A
E
Dog
Lupus familis
XP_858235
652
70722
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q7M6Y3
660
71525
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Rat
Rattus norvegicus
O55012
640
69267
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512668
642
69699
I241
K
V
A
E
Q
V
G
I
D
R
G
D
I
P
D
Chicken
Gallus gallus
XP_423671
651
70667
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Frog
Xenopus laevis
NP_001085333
444
49230
G66
L
D
R
G
A
M
Q
G
Y
D
M
S
T
F
I
Zebra Danio
Brachydanio rerio
NP_957221
589
63960
Y211
A
I
R
L
F
A
A
Y
N
E
G
I
I
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VI75
468
49849
Y90
T
T
H
H
L
M
A
Y
G
N
E
R
F
M
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XZI6
586
64045
G208
T
T
S
E
L
N
N
G
V
I
N
C
S
F
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53309
568
64310
G190
L
L
V
Q
D
L
L
G
L
Y
N
A
L
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.2
45
99.3
N.A.
96.5
96.1
N.A.
89.7
94.1
47
77.1
N.A.
41.4
N.A.
38.7
N.A.
Protein Similarity:
100
81.3
56
99.6
N.A.
97.7
96.9
N.A.
92.1
97.3
57.6
83.4
N.A.
54.2
N.A.
55.6
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
100
100
N.A.
0
100
13.3
6.6
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
20
26.6
N.A.
20
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
8
8
16
0
0
0
0
8
0
54
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
0
0
8
0
0
0
8
8
0
8
0
0
8
% D
% Glu:
0
0
0
16
0
0
0
0
54
8
8
0
0
0
62
% E
% Phe:
0
0
0
0
8
0
0
0
0
54
0
0
8
16
0
% F
% Gly:
0
0
0
8
0
0
8
24
8
0
16
0
0
0
0
% G
% His:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
47
8
0
8
0
8
16
0
16
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% K
% Leu:
70
8
0
8
16
8
8
0
8
0
54
0
8
0
8
% L
% Met:
0
0
0
54
0
16
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
8
0
8
8
16
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
8
8
0
8
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
70
0
0
54
0
0
0
8
0
8
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
54
0
0
0
8
8
8
0
% S
% Thr:
16
70
0
0
54
0
0
0
0
0
0
0
8
0
0
% T
% Val:
0
8
8
0
0
8
8
0
8
0
0
0
54
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
16
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _