KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPYD
All Species:
36.06
Human Site:
Y600
Identified Species:
72.12
UniProt:
Q12882
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12882
NP_000101.2
1025
111401
Y600
G
T
T
S
G
P
M
Y
G
P
G
Q
S
S
F
Chimpanzee
Pan troglodytes
XP_513583
1219
132523
Y794
G
T
T
S
G
P
M
Y
G
P
G
Q
S
S
F
Rhesus Macaque
Macaca mulatta
XP_001106007
1025
111542
Y600
G
T
T
S
G
P
M
Y
G
P
G
Q
S
S
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHR6
1025
111235
Y600
G
T
T
S
G
P
L
Y
G
P
G
Q
S
S
F
Rat
Rattus norvegicus
O89000
1025
111449
Y600
G
T
T
S
G
P
L
Y
G
P
G
Q
S
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426639
1178
126824
Y753
G
V
T
S
G
P
I
Y
G
P
G
Q
G
S
F
Frog
Xenopus laevis
NP_001087488
940
101737
R561
T
T
S
A
P
M
I
R
R
A
F
E
A
G
W
Zebra Danio
Brachydanio rerio
Q6NYG8
1022
110985
F600
G
T
T
S
G
H
I
F
G
P
G
Q
G
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572538
1031
111207
Y595
G
T
T
S
G
Y
K
Y
G
P
Q
Q
G
C
F
Honey Bee
Apis mellifera
XP_393690
1024
112012
Y598
G
T
T
S
R
H
H
Y
G
P
E
Q
G
S
F
Nematode Worm
Caenorhab. elegans
Q18164
1059
115282
Y614
G
S
T
S
G
P
L
Y
G
P
N
Q
G
S
F
Sea Urchin
Strong. purpuratus
XP_001177822
1025
111109
Y600
G
T
T
S
G
N
V
Y
G
P
G
Q
G
S
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.8
98.3
N.A.
N.A.
89.5
89.1
N.A.
N.A.
72.4
74.2
76.2
N.A.
65.6
66.8
63.9
71.3
Protein Similarity:
100
83.8
99.3
N.A.
N.A.
94.9
94.4
N.A.
N.A.
79.1
82.2
86.4
N.A.
76.8
80.7
77.1
83.7
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
80
6.6
73.3
N.A.
66.6
66.6
73.3
80
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
86.6
46.6
86.6
N.A.
66.6
66.6
86.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
0
9
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
92
% F
% Gly:
92
0
0
0
84
0
0
0
92
0
67
0
50
9
0
% G
% His:
0
0
0
0
0
17
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
9
25
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
9
59
0
0
0
92
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
9
92
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
9
9
0
0
0
0
0
0
% R
% Ser:
0
9
9
92
0
0
0
0
0
0
0
0
42
84
0
% S
% Thr:
9
84
92
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
9
0
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _