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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPYD
All Species:
32.12
Human Site:
Y222
Identified Species:
64.24
UniProt:
Q12882
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12882
NP_000101.2
1025
111401
Y222
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Chimpanzee
Pan troglodytes
XP_513583
1219
132523
Y416
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Rhesus Macaque
Macaca mulatta
XP_001106007
1025
111542
Y222
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHR6
1025
111235
Y222
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Rat
Rattus norvegicus
O89000
1025
111449
Y222
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426639
1178
126824
Y382
T
I
F
E
K
Q
E
Y
V
G
G
L
S
A
S
Frog
Xenopus laevis
NP_001087488
940
101737
Y222
T
I
F
E
K
Q
T
Y
F
G
G
L
S
T
S
Zebra Danio
Brachydanio rerio
Q6NYG8
1022
110985
Y222
T
I
F
E
K
Q
K
Y
I
G
G
L
S
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572538
1031
111207
S224
R
S
Y
L
G
G
L
S
A
A
E
I
P
Q
Y
Honey Bee
Apis mellifera
XP_393690
1024
112012
S224
Q
N
Y
I
G
G
L
S
S
S
E
I
P
Q
Y
Nematode Worm
Caenorhab. elegans
Q18164
1059
115282
G237
Y
E
K
R
A
Y
I
G
G
L
S
S
A
E
I
Sea Urchin
Strong. purpuratus
XP_001177822
1025
111109
W222
T
V
F
E
K
E
E
W
I
G
G
L
S
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.8
98.3
N.A.
N.A.
89.5
89.1
N.A.
N.A.
72.4
74.2
76.2
N.A.
65.6
66.8
63.9
71.3
Protein Similarity:
100
83.8
99.3
N.A.
N.A.
94.9
94.4
N.A.
N.A.
79.1
82.2
86.4
N.A.
76.8
80.7
77.1
83.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
93.3
86.6
86.6
N.A.
0
0
0
60
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
93.3
86.6
100
N.A.
13.3
13.3
6.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
9
9
0
0
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
0
75
0
9
59
0
0
0
17
0
0
9
0
% E
% Phe:
0
0
75
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
17
17
0
9
9
75
75
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
67
0
9
0
0
9
0
17
0
0
17
0
0
9
% I
% Lys:
0
0
9
0
75
0
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
9
0
0
17
0
0
9
0
75
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% P
% Gln:
9
0
0
0
0
67
0
0
0
0
0
0
0
17
0
% Q
% Arg:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
9
0
0
0
0
0
17
9
9
9
9
75
9
67
% S
% Thr:
75
0
0
0
0
0
9
0
0
0
0
0
0
59
0
% T
% Val:
0
9
0
0
0
0
0
0
50
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
9
0
17
0
0
9
0
67
0
0
0
0
0
0
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _