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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPYD
All Species:
15.45
Human Site:
S905
Identified Species:
30.91
UniProt:
Q12882
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12882
NP_000101.2
1025
111401
S905
K
E
Q
N
V
A
F
S
P
L
K
R
N
C
F
Chimpanzee
Pan troglodytes
XP_513583
1219
132523
S1099
K
E
Q
N
V
A
F
S
P
L
K
R
N
C
F
Rhesus Macaque
Macaca mulatta
XP_001106007
1025
111542
S905
K
E
Q
N
A
A
F
S
P
L
K
R
N
C
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHR6
1025
111235
S905
K
D
Q
N
T
A
C
S
P
L
Q
R
K
H
F
Rat
Rattus norvegicus
O89000
1025
111449
S905
N
D
Q
N
R
A
C
S
P
L
Q
R
K
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426639
1178
126824
V1058
K
E
Q
G
T
A
A
V
L
P
E
K
K
H
F
Frog
Xenopus laevis
NP_001087488
940
101737
I827
Q
N
Q
D
F
T
V
I
E
D
Y
C
T
G
L
Zebra Danio
Brachydanio rerio
Q6NYG8
1022
110985
D904
A
S
G
D
V
I
M
D
T
G
A
A
R
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572538
1031
111207
K905
L
W
D
A
E
Q
V
K
A
T
P
P
A
S
N
Honey Bee
Apis mellifera
XP_393690
1024
112012
V901
S
N
P
L
D
N
L
V
E
T
T
R
S
S
P
Nematode Worm
Caenorhab. elegans
Q18164
1059
115282
Y916
N
L
L
D
T
E
N
Y
H
F
A
S
R
P
D
Sea Urchin
Strong. purpuratus
XP_001177822
1025
111109
P905
L
T
G
D
D
Q
Q
P
A
P
Q
R
P
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.8
98.3
N.A.
N.A.
89.5
89.1
N.A.
N.A.
72.4
74.2
76.2
N.A.
65.6
66.8
63.9
71.3
Protein Similarity:
100
83.8
99.3
N.A.
N.A.
94.9
94.4
N.A.
N.A.
79.1
82.2
86.4
N.A.
76.8
80.7
77.1
83.7
P-Site Identity:
100
100
93.3
N.A.
N.A.
60
53.3
N.A.
N.A.
33.3
6.6
6.6
N.A.
0
6.6
0
6.6
P-Site Similarity:
100
100
93.3
N.A.
N.A.
73.3
66.6
N.A.
N.A.
46.6
20
13.3
N.A.
0
13.3
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
9
50
9
0
17
0
17
9
9
9
0
% A
% Cys:
0
0
0
0
0
0
17
0
0
0
0
9
0
25
0
% C
% Asp:
0
17
9
34
17
0
0
9
0
9
0
0
0
0
9
% D
% Glu:
0
34
0
0
9
9
0
0
17
0
9
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
25
0
0
9
0
0
0
0
50
% F
% Gly:
0
0
17
9
0
0
0
0
0
9
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
9
0
0
0
0
25
0
% H
% Ile:
0
0
0
0
0
9
0
9
0
0
0
0
0
0
0
% I
% Lys:
42
0
0
0
0
0
0
9
0
0
25
9
25
0
0
% K
% Leu:
17
9
9
9
0
0
9
0
9
42
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
17
17
0
42
0
9
9
0
0
0
0
0
25
0
17
% N
% Pro:
0
0
9
0
0
0
0
9
42
17
9
9
9
9
9
% P
% Gln:
9
0
59
0
0
17
9
0
0
0
25
0
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
0
0
0
59
17
0
9
% R
% Ser:
9
9
0
0
0
0
0
42
0
0
0
9
9
17
0
% S
% Thr:
0
9
0
0
25
9
0
0
9
17
9
0
9
0
0
% T
% Val:
0
0
0
0
25
0
17
17
0
0
0
0
0
9
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _