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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPYD
All Species:
9.09
Human Site:
S1020
Identified Species:
18.18
UniProt:
Q12882
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12882
NP_000101.2
1025
111401
S1020
P
K
R
G
V
P
L
S
V
N
P
V
C
_
_
Chimpanzee
Pan troglodytes
XP_513583
1219
132523
S1214
P
K
R
G
V
P
L
S
V
N
P
V
C
_
_
Rhesus Macaque
Macaca mulatta
XP_001106007
1025
111542
S1020
P
K
R
G
V
P
L
S
V
D
P
V
C
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHR6
1025
111235
A1020
P
K
R
G
L
P
L
A
V
K
P
V
C
_
_
Rat
Rattus norvegicus
O89000
1025
111449
A1020
P
K
R
G
L
P
L
A
V
K
P
V
C
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426639
1178
126824
A1173
P
R
R
G
L
P
L
A
L
S
P
L
C
_
_
Frog
Xenopus laevis
NP_001087488
940
101737
Zebra Danio
Brachydanio rerio
Q6NYG8
1022
110985
P1017
Y
E
P
K
R
G
L
P
V
N
P
V
C
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572538
1031
111207
K1020
I
K
R
G
V
E
E
K
I
F
Y
T
H
A
L
Honey Bee
Apis mellifera
XP_393690
1024
112012
K1016
I
N
R
G
V
P
L
K
E
C
F
N
F
E
I
Nematode Worm
Caenorhab. elegans
Q18164
1059
115282
K1031
K
A
P
K
R
G
V
K
P
S
V
E
P
G
T
Sea Urchin
Strong. purpuratus
XP_001177822
1025
111109
A1020
P
Y
R
G
I
P
L
A
V
G
T
S
S
_
_
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.8
98.3
N.A.
N.A.
89.5
89.1
N.A.
N.A.
72.4
74.2
76.2
N.A.
65.6
66.8
63.9
71.3
Protein Similarity:
100
83.8
99.3
N.A.
N.A.
94.9
94.4
N.A.
N.A.
79.1
82.2
86.4
N.A.
76.8
80.7
77.1
83.7
P-Site Identity:
100
100
92.3
N.A.
N.A.
76.9
76.9
N.A.
N.A.
53.8
0
46.1
N.A.
26.6
33.3
0
46.1
P-Site Similarity:
100
100
100
N.A.
N.A.
92.3
92.3
N.A.
N.A.
100
0
53.8
N.A.
33.3
40
20
61.5
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
34
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
59
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
9
0
0
0
9
9
0
9
0
0
9
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
9
0
9
0
0
% F
% Gly:
0
0
0
75
0
17
0
0
0
9
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
17
0
0
0
9
0
0
0
9
0
0
0
0
0
9
% I
% Lys:
9
50
0
17
0
0
0
25
0
17
0
0
0
0
0
% K
% Leu:
0
0
0
0
25
0
75
0
9
0
0
9
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
25
0
9
0
0
0
% N
% Pro:
59
0
17
0
0
67
0
9
9
0
59
0
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
75
0
17
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
25
0
17
0
9
9
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
9
% T
% Val:
0
0
0
0
42
0
9
0
59
0
9
50
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
67
% _