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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF1 All Species: 5.76
Human Site: Y461 Identified Species: 10.56
UniProt: Q10570 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q10570 NP_037423.2 1443 160884 Y461 S G T Q L A T Y S F E V C D S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532356 1499 165986 S519 G T Q L A T Y S F E V C D S I
Cat Felis silvestris
Mouse Mus musculus Q9EPU4 1441 160800 S461 G T Q L A T Y S F E V C D S M
Rat Rattus norvegicus NP_001124043 1386 154862 E461 Q L A T Y S F E V C D S M L N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514888 831 91833
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001108153 1449 162918 Y461 S G T Q L A T Y S F E V C D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V726 1455 164663 A472 L E V Y G S G A K A S V L Q L
Honey Bee Apis mellifera XP_624382 1415 160872 Q463 S E T H T S I Q I T S Y I F E
Nematode Worm Caenorhab. elegans Q9N4C2 1454 162698 N448 R E L D R L R N V G P V K S M
Sea Urchin Strong. purpuratus XP_789715 1220 135970 K330 K E A K A D E K S E E S E A S
Poplar Tree Populus trichocarpa XP_002318462 1455 159431 I503 S S Q V V S V I K T F S F T V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FGR0 1442 158057 A506 A Q K S F S F A V R D S L V N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SEY2 1456 158155 S478 G Q T Q K R K S R L Q D A D L
Conservation
Percent
Protein Identity: 100 N.A. N.A. 90.8 N.A. 96.5 92.8 N.A. 50.6 N.A. N.A. 79.6 N.A. 46.7 54.3 31.5 47.6
Protein Similarity: 100 N.A. N.A. 92.5 N.A. 98 94.3 N.A. 53.3 N.A. N.A. 89.2 N.A. 65.5 71 52.2 60.7
P-Site Identity: 100 N.A. N.A. 0 N.A. 0 0 N.A. 0 N.A. N.A. 100 N.A. 6.6 13.3 6.6 20
P-Site Similarity: 100 N.A. N.A. 0 N.A. 0 20 N.A. 0 N.A. N.A. 100 N.A. 13.3 20 6.6 26.6
Percent
Protein Identity: 33.1 N.A. N.A. 32.8 N.A. 28
Protein Similarity: 51.6 N.A. N.A. 51.8 N.A. 48.7
P-Site Identity: 6.6 N.A. N.A. 0 N.A. 20
P-Site Similarity: 20 N.A. N.A. 26.6 N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 0 24 16 0 16 0 8 0 0 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 16 16 0 0 % C
% Asp: 0 0 0 8 0 8 0 0 0 0 16 8 16 24 0 % D
% Glu: 0 31 0 0 0 0 8 8 0 24 24 0 8 0 8 % E
% Phe: 0 0 0 0 8 0 16 0 16 16 8 0 8 8 0 % F
% Gly: 24 16 0 0 8 0 8 0 0 8 0 0 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 8 8 0 0 0 8 0 8 % I
% Lys: 8 0 8 8 8 0 8 8 16 0 0 0 8 0 0 % K
% Leu: 8 8 8 16 16 8 0 0 0 8 0 0 16 8 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 16 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 16 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 8 16 24 24 0 0 0 8 0 0 8 0 0 8 0 % Q
% Arg: 8 0 0 0 8 8 8 0 8 8 0 0 0 0 0 % R
% Ser: 31 8 0 8 0 39 0 24 24 0 16 31 0 24 24 % S
% Thr: 0 16 31 8 8 16 16 0 0 16 0 0 0 8 0 % T
% Val: 0 0 8 8 8 0 8 0 24 0 16 31 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 0 16 16 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _