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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF1 All Species: 16.06
Human Site: S859 Identified Species: 29.44
UniProt: Q10570 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q10570 NP_037423.2 1443 160884 S859 V A L G S R Q S R P Y L L V H
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532356 1499 165986 S915 V A L G S R Q S R P Y L L V H
Cat Felis silvestris
Mouse Mus musculus Q9EPU4 1441 160800 S857 V A L G S R Q S R P Y L L V H
Rat Rattus norvegicus NP_001124043 1386 154862 K841 Q G E L P L V K E V L L V A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514888 831 91833 G297 C D S I L N I G P C A N A A M
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001108153 1449 162918 S865 V S L G Y N H S R P Y L L A H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V726 1455 164663 E875 I G L G L N G E R P L L L V R
Honey Bee Apis mellifera XP_624382 1415 160872 N841 V A L G H H G N R P M L L V R
Nematode Worm Caenorhab. elegans Q9N4C2 1454 162698 A866 V G M G I N Q A H P I L M A I
Sea Urchin Strong. purpuratus XP_789715 1220 135970 K686 P T A E G G T K P E T E T E A
Poplar Tree Populus trichocarpa XP_002318462 1455 159431 G889 Y L F E G P D G T S K L E D S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FGR0 1442 158057 T870 F A V L A D G T I L C Y H A Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SEY2 1456 158155 S859 L G D T T H K S P Y L I L R H
Conservation
Percent
Protein Identity: 100 N.A. N.A. 90.8 N.A. 96.5 92.8 N.A. 50.6 N.A. N.A. 79.6 N.A. 46.7 54.3 31.5 47.6
Protein Similarity: 100 N.A. N.A. 92.5 N.A. 98 94.3 N.A. 53.3 N.A. N.A. 89.2 N.A. 65.5 71 52.2 60.7
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 6.6 N.A. 0 N.A. N.A. 66.6 N.A. 46.6 60 33.3 0
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 13.3 N.A. 0 N.A. N.A. 73.3 N.A. 53.3 66.6 53.3 0
Percent
Protein Identity: 33.1 N.A. N.A. 32.8 N.A. 28
Protein Similarity: 51.6 N.A. N.A. 51.8 N.A. 48.7
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. 20
P-Site Similarity: 6.6 N.A. N.A. 33.3 N.A. 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 39 8 0 8 0 0 8 0 0 8 0 8 39 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % C
% Asp: 0 8 8 0 0 8 8 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 8 16 0 0 0 8 8 8 0 8 8 8 0 % E
% Phe: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 31 0 54 16 8 24 16 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 16 8 0 8 0 0 0 8 0 39 % H
% Ile: 8 0 0 8 8 0 8 0 8 0 8 8 0 0 8 % I
% Lys: 0 0 0 0 0 0 8 16 0 0 8 0 0 0 0 % K
% Leu: 8 8 47 16 16 8 0 0 0 8 24 70 54 0 8 % L
% Met: 0 0 8 0 0 0 0 0 0 0 8 0 8 0 8 % M
% Asn: 0 0 0 0 0 31 0 8 0 0 0 8 0 0 0 % N
% Pro: 8 0 0 0 8 8 0 0 24 54 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 31 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 24 0 0 47 0 0 0 0 8 16 % R
% Ser: 0 8 8 0 24 0 0 39 0 8 0 0 0 0 8 % S
% Thr: 0 8 0 8 8 0 8 8 8 0 8 0 8 0 0 % T
% Val: 47 0 8 0 0 0 8 0 0 8 0 0 8 39 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 8 0 0 0 0 8 31 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _