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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC9
All Species:
17.27
Human Site:
S425
Identified Species:
29.23
UniProt:
Q06265
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06265
NP_001029366.1
439
48949
S425
A
K
Q
E
K
A
P
S
K
K
P
V
K
R
R
Chimpanzee
Pan troglodytes
XP_001154164
439
48943
S425
A
K
Q
E
K
A
P
S
K
K
P
V
K
R
R
Rhesus Macaque
Macaca mulatta
XP_001101063
442
49364
S428
A
K
Q
E
K
A
P
S
K
K
P
V
K
R
R
Dog
Lupus familis
XP_533302
440
49215
S426
A
K
Q
E
K
A
P
S
K
K
P
V
K
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI7
438
48918
G426
N
Q
K
A
P
S
K
G
Q
G
K
R
K
K
K
Rat
Rattus norvegicus
Q4QR75
437
48863
S425
N
Q
K
A
P
S
K
S
Q
G
K
R
R
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513016
439
49457
K427
K
K
E
A
I
N
K
K
A
T
N
K
K
R
K
Chicken
Gallus gallus
NP_001030000
440
49356
K427
K
Q
E
S
T
S
K
K
A
F
N
K
K
R
R
Frog
Xenopus laevis
NP_001085439
431
48014
A420
S
A
S
D
I
S
S
A
K
K
K
K
K
N
K
Zebra Danio
Brachydanio rerio
NP_001006077
393
44117
L381
E
E
E
E
V
V
I
L
N
D
Q
K
S
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624243
396
44894
L389
E
E
E
T
T
E
M
L
N
K
E
D
L
M
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788833
437
48874
G422
R
G
N
T
R
A
K
G
G
K
K
K
W
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_191609
438
48277
L424
H
K
D
G
E
M
T
L
K
D
A
V
K
P
K
Baker's Yeast
Sacchar. cerevisiae
Q05636
305
33943
T298
N
K
Y
A
A
M
L
T
S
E
N
A
R
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
92.9
95.9
N.A.
92.4
92.9
N.A.
82.4
78.4
72.4
66.9
N.A.
N.A.
33.2
N.A.
48.5
Protein Similarity:
100
99.7
94.3
98.1
N.A.
95.9
95.9
N.A.
90.4
87.9
83.8
79.5
N.A.
N.A.
55.8
N.A.
69
P-Site Identity:
100
100
100
93.3
N.A.
6.6
6.6
N.A.
20
20
20
6.6
N.A.
N.A.
6.6
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
46.6
53.3
N.A.
33.3
40
53.3
33.3
N.A.
N.A.
26.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.5
28.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
45.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
8
0
29
8
36
0
8
15
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
0
0
15
0
8
0
0
0
% D
% Glu:
15
15
29
36
8
8
0
0
0
8
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
8
0
0
0
15
8
15
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
15
0
8
0
0
0
0
0
0
0
8
% I
% Lys:
15
50
15
0
29
0
36
15
43
50
29
36
65
36
50
% K
% Leu:
0
0
0
0
0
0
8
22
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
15
8
0
0
0
0
0
0
8
0
% M
% Asn:
22
0
8
0
0
8
0
0
15
0
22
0
0
8
0
% N
% Pro:
0
0
0
0
15
0
29
0
0
0
29
0
0
8
0
% P
% Gln:
0
22
29
0
0
0
0
0
15
0
8
0
0
0
8
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
15
15
36
36
% R
% Ser:
8
0
8
8
0
29
8
36
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
15
15
0
8
8
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
8
8
0
0
0
0
0
36
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _