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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R3A
All Species:
4.55
Human Site:
T463
Identified Species:
8.33
UniProt:
Q06190
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06190
NP_002709.2
1150
130278
T463
T
H
L
K
K
C
P
T
P
M
Q
N
E
I
G
Chimpanzee
Pan troglodytes
XP_001153482
1150
130149
T463
T
H
L
K
R
C
P
T
P
M
Q
N
E
I
G
Rhesus Macaque
Macaca mulatta
XP_001115107
1150
130076
A463
T
H
L
K
K
C
P
A
S
M
Q
N
E
I
G
Dog
Lupus familis
XP_542792
1152
130075
P462
G
T
P
L
K
K
Y
P
A
S
V
Q
N
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z176
491
55687
Rat
Rattus norvegicus
NP_001012202
1150
129888
P462
Y
L
K
K
C
P
A
P
V
Q
N
E
I
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518335
657
71327
V9
A
A
A
Y
R
L
V
V
S
T
V
N
C
Y
N
Chicken
Gallus gallus
XP_422556
1117
125703
G460
K
A
E
P
T
R
V
G
S
E
L
S
H
T
S
Frog
Xenopus laevis
NP_001082623
1127
126700
Q469
K
P
S
R
K
S
V
Q
S
H
R
P
V
D
P
Zebra Danio
Brachydanio rerio
XP_694203
1163
130076
G486
T
G
Y
S
E
P
S
G
G
V
S
D
K
L
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650842
888
97842
R240
A
A
T
V
G
K
K
R
Q
N
S
K
A
N
S
Honey Bee
Apis mellifera
XP_396366
1240
138144
P510
V
P
L
T
R
Q
K
P
A
I
K
R
E
K
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784322
739
85352
A91
Y
G
F
C
T
V
V
A
R
P
P
G
V
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
90.4
N.A.
27.8
85
N.A.
34
59.6
54
55.5
N.A.
32.6
30.7
N.A.
31.1
Protein Similarity:
100
99.7
98.8
94.6
N.A.
34.5
91
N.A.
43.1
73.3
68.7
70.8
N.A.
47.7
47.1
N.A.
45
P-Site Identity:
100
93.3
86.6
6.6
N.A.
0
6.6
N.A.
6.6
0
6.6
6.6
N.A.
0
13.3
N.A.
6.6
P-Site Similarity:
100
100
86.6
6.6
N.A.
0
6.6
N.A.
13.3
6.6
20
40
N.A.
0
33.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
24
8
0
0
0
8
16
16
0
0
0
8
0
0
% A
% Cys:
0
0
0
8
8
24
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% D
% Glu:
0
0
8
0
8
0
0
0
0
8
0
8
31
8
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
16
0
0
8
0
0
16
8
0
0
8
0
0
24
% G
% His:
0
24
0
0
0
0
0
0
0
8
0
0
8
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
8
31
0
% I
% Lys:
16
0
8
31
31
16
16
0
0
0
8
8
8
8
8
% K
% Leu:
0
8
31
8
0
8
0
0
0
0
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
24
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
8
31
8
8
8
% N
% Pro:
0
16
8
8
0
16
24
24
16
8
8
8
0
0
24
% P
% Gln:
0
0
0
0
0
8
0
8
8
8
24
8
0
0
0
% Q
% Arg:
0
0
0
8
24
8
0
8
8
0
8
8
0
0
0
% R
% Ser:
0
0
8
8
0
8
8
0
31
8
16
8
0
8
24
% S
% Thr:
31
8
8
8
16
0
0
16
0
8
0
0
0
8
0
% T
% Val:
8
0
0
8
0
8
31
8
8
8
16
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
8
8
0
0
8
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _