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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R3A
All Species:
9.39
Human Site:
S476
Identified Species:
17.22
UniProt:
Q06190
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06190
NP_002709.2
1150
130278
S476
I
G
K
I
F
E
K
S
F
V
N
L
P
K
E
Chimpanzee
Pan troglodytes
XP_001153482
1150
130149
S476
I
G
K
I
F
E
K
S
F
V
N
L
P
K
E
Rhesus Macaque
Macaca mulatta
XP_001115107
1150
130076
S476
I
G
K
I
F
E
K
S
F
V
H
L
P
K
E
Dog
Lupus familis
XP_542792
1152
130075
K475
E
S
D
K
I
F
E
K
S
V
N
L
P
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z176
491
55687
Rat
Rattus norvegicus
NP_001012202
1150
129888
M475
S
K
I
F
E
K
P
M
V
V
R
P
P
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518335
657
71327
R22
Y
N
S
V
V
I
D
R
R
F
Q
Q
A
V
H
Chicken
Gallus gallus
XP_422556
1117
125703
L473
T
S
E
K
S
N
L
L
K
P
V
S
N
S
V
Frog
Xenopus laevis
NP_001082623
1127
126700
N482
D
P
S
M
I
L
S
N
N
T
S
F
S
S
N
Zebra Danio
Brachydanio rerio
XP_694203
1163
130076
G499
L
H
E
L
S
R
N
G
T
T
F
K
P
Q
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650842
888
97842
S253
N
S
S
S
S
I
N
S
N
H
I
G
N
S
A
Honey Bee
Apis mellifera
XP_396366
1240
138144
K523
K
P
K
V
E
P
V
K
P
I
I
I
G
H
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784322
739
85352
I104
I
P
R
D
D
E
D
I
E
E
K
R
K
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
90.4
N.A.
27.8
85
N.A.
34
59.6
54
55.5
N.A.
32.6
30.7
N.A.
31.1
Protein Similarity:
100
99.7
98.8
94.6
N.A.
34.5
91
N.A.
43.1
73.3
68.7
70.8
N.A.
47.7
47.1
N.A.
45
P-Site Identity:
100
100
93.3
33.3
N.A.
0
26.6
N.A.
0
0
0
6.6
N.A.
6.6
6.6
N.A.
13.3
P-Site Similarity:
100
100
100
46.6
N.A.
0
33.3
N.A.
6.6
6.6
20
33.3
N.A.
6.6
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
8
8
0
16
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
16
0
16
31
8
0
8
8
0
0
0
8
39
% E
% Phe:
0
0
0
8
24
8
0
0
24
8
8
8
0
0
0
% F
% Gly:
0
24
0
0
0
0
0
8
0
0
0
8
8
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
8
8
0
0
8
8
% H
% Ile:
31
0
8
24
16
16
0
8
0
8
16
8
0
0
0
% I
% Lys:
8
8
31
16
0
8
24
16
8
0
8
8
8
31
0
% K
% Leu:
8
0
0
8
0
8
8
8
0
0
0
31
0
0
0
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
0
0
8
16
8
16
0
24
0
16
0
24
% N
% Pro:
0
24
0
0
0
8
8
0
8
8
0
8
47
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% Q
% Arg:
0
0
8
0
0
8
0
8
8
0
8
8
0
0
0
% R
% Ser:
8
24
24
8
24
0
8
31
8
0
8
8
8
31
8
% S
% Thr:
8
0
0
0
0
0
0
0
8
16
0
0
0
0
0
% T
% Val:
0
0
0
16
8
0
8
0
8
39
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _